Overview
| Uniprot ID | A0A8I5ZTU5 |
|---|
| Protein Name | Ran-specific GTPase-activating protein |
|---|
| Gene Name | Ranbp1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 198 |
ARDEAEEKSEEKQ** |
Function
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP
Protein Sequence
10
MAAAKDSHED
20
HDTSTENAEE
30
SNHDPQFEPI
40
VSLPEQEIKT
50
LEEDEEELFK
60
MRAKLFRFAS
70
ENDLPEWKER
80
GTGDVKLLKH
90
KEKGTIRLLM
100
RRDKTLKICA
110
NHYITPMMEL
120
KPNAGSDRAW
130
VWNTHADFAD
140
ECPKPELLAI
150
RFLNAENAQK
160
FKTKFEECRK
170
EIEEREKKGP
180
GKNDNAEKVA
190
EKLEALSVRE
200
ARDEAEEKSE
EKQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1904115 |
axon cytoplasm |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005643 |
nuclear pore |
| Cellular Component |
GO:0032838 |
plasma membrane bounded cell projection cytoplasm |
| Molecular Function |
GO:0005092 |
GDP-dissociation inhibitor activity |
| Biological Process |
GO:0072750 |
cellular response to leptomycin B |
| Biological Process |
GO:0071466 |
cellular response to xenobiotic stimulus |
| Biological Process |
GO:0051168 |
nuclear export |
| Biological Process |
GO:0046604 |
positive regulation of mitotic centrosome separation |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0051592 |
response to calcium ion |
| Biological Process |
GO:0007051 |
spindle organization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.