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Overview

Uniprot IDA0A8I5ZU81
Protein NameFerritin
Gene NameFth1-ps5
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
147 NEQVKSIKELGDHVT
69 EEREHAEKLMKLQNQ
72 EHAEKLMKLQNQRGG

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation

Protein Sequence

10 MTTASPSQVR 20 QNYHQDSEAA 30 INRQINLELY 40 ASYVYLSMSC 50 YFDRDGVALK 60 NFAKYFLHQS 70 HEEREHAEKL 80 MKLQNQRGGR 90 IFLQDIKKPD 100 RDDWESGLNA 110 MECALHLEKS 120 VNQSLLELHK 130 LATDKNDPHL 140 CDFIETHYLN 150 EQVKSIKELG 160 DHVTNLRKMG 170 APESGMAEYL 180 FDKHTLGQGD ES

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005776 autophagosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005764 lysosome
Molecular Function GO:0008199 ferric iron binding
Molecular Function GO:0008198 ferrous iron binding
Molecular Function GO:0004322 ferroxidase activity
Biological Process GO:0006879 intracellular iron ion homeostasis
Biological Process GO:0006826 iron ion transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.