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Overview

Uniprot IDA0A8I5ZUV1
Protein NameCytochrome c oxidase subunit 4
Gene NameCox4i1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
114 KLLSASQKALKEKEK
121 KALKEKEKADWSSLS
132 SSLSRDEKVQLYRIQ
197 DWVAMQTKRMLDMKV
83 RAHGSVVKSEDYALP

Function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation

Protein Sequence

10 MDVGGASSIP 20 AMLRGTVLLF 30 RCGTRSSGRE 40 HPGCRGRSRR 50 SPGQQWQVTA 60 FDSGMLATRA 70 LSLIGKRAIS 80 TSVCLRAHGS 90 VVKSEDYALP 100 SYVDRRDYPL 110 PDVAHVKLLS 120 ASQKALKEKE 130 KADWSSLSRD 140 EKVQLYRIQF 150 NESFAEMNKG 160 TNEWKTVVGL 170 AMFFIGFTAL 180 VLIWEKSYVY 190 GPIPHTFDRD 200 WVAMQTKRML 210 DMKVNPIQGF 220 SAKWDYNKNE WKK

Gene Ontology

Classification GO ID Description
Biological Process GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0045277 respiratory chain complex IV

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.