Search Results
Overview
| Uniprot ID | A0A8I5ZV34 |
|---|---|
| Protein Name | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial |
| Gene Name | Suclg2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | GVFDSGLKGGVHLTK |
| 49 | LQEYQSKKLMSEHGV |
| 68 | FFVASTAKEAQEAAK |
| 95 | ILAGGRGKGVFDSGL |
Function
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase
Protein Sequence
10
MASAVAIAAQ
20
AGKLLRERSL
30
RPRLLAVRSQ
40
AGHLTPRRWL
50
NLQEYQSKKL
60
MSEHGVRVQR
70
FFVASTAKEA
80
QEAAKRLNAK
90
EIVLKAQILA
100
GGRGKGVFDS
110
GLKGGVHLTK
120
DPKVVGQLAQ
130
QMIGYNLATK
140
QTPKEGVKVN
150
KVMVAEALDI
160
SRETYLAILM
170
DRSHNGPVLV
180
GSPQGGVDIE
190
EVAASSPELI
200
FKEQIDIFEG
210
IKDSQAQRMA
220
ENLGFLGSLK
230
NQAADQIKKL
240
YHLFLKIDAT
250
QVEVNPFGET
260
PEGQVVCFDA
270
KINFDDNAEF
280
RQKDIFAMDD
290
KSENEPIENE
300
AARYDLKYIG
310
LDGNIACFVN
320
GAGLAMATCD
330
IIFLNGGKPA
340
NFLDLGGGVK
350
ESQVYQAFKL
360
LTSDPKVEAI
370
LVNIFGGIVN
380
CAIIANGITK
390
ACQELELKVP
400
LVVRLEGSCP
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Biological Process | GO:0006104 | succinyl-CoA metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.