Overview
| Uniprot ID | A0A8I5ZVH7 |
|---|
| Protein Name | Vesicle-associated membrane protein-associated protein A |
|---|
| Gene Name | Vapa |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 195 |
AVPLNASKQDGPLPK |
| 246 |
DEGLRLRKVAHSDKP |
| 252 |
RKVAHSDKPGSTSAV |
Function
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking
Protein Sequence
10
MASASGAMAK
20
HEQILVLDPP
30
SDLKFKGPFT
40
DVVTTNLKLQ
50
NPSDRKVCFK
60
VKTTAPRRYC
70
VRPNSGVIDP
80
GSIVTVSVML
90
QPFDYDPNEK
100
SKHKFMVQTI
110
FAPPNISDME
120
AVWKEAKPDE
130
LMDSKLRCVF
140
EMPNENDKLG
150
KTLPGIASAV
160
TSVSSISSTV
170
ATPASYHMKS
180
DPRELKEVKQ
190
NDMEPSKAVP
200
LNASKQDGPL
210
PKPHSVSLND
220
TETRKLMEEC
230
KRLQGEMMKL
240
SEENRHLRDE
250
GLRLRKVAHS
260
DKPGSTSAVS
270
FRDNVTSPLP
280
SLLVVIAAIF
290
IGFFLGKFIL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0005886 |
plasma membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.