Search Results
Overview
| Uniprot ID | A0A8I5ZXA6 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial |
| Gene Name | Ndufv2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 217 | LRAGKVPKPGPRSGR |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster
Protein Sequence
10
MYLYACFLIL
20
LREKGIGCRP
30
GRHARNLHKT
40
AVQNGAGGAL
50
FVHRDTPENN
60
PDTPFDFTPE
70
NYERIEAIVR
80
NYPEGHRAAA
90
VLPVLDLAQR
100
QNGWLPISAM
110
NKVAEVLQVP
120
PMRVYEVATF
130
YTMYNRKPVG
140
KYHIQVCTTT
150
PCMLRDSDSI
160
LETLQRKLGI
170
KVGETTPDKL
180
FTLIEVECLG
190
ACVNAPMVQI
200
NDDYYEDLTP
210
KDIEEIIDEL
220
RAGKVPKPGP
230
RSGRFCCEPA
240
GGLTSLTEPP
250
KGPGFGVQAG
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.