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Overview

Uniprot IDA0A8I5ZXM3
Protein NameNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Gene NameNdufs1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
411 LFNARIRKSWLHNDL
455 SGNHEFSKVLNAAKK
462 KVLNAAKKPMVVLGS
598 EGRAQQTKVAVTPPG
700 RASQTMAKCVKAVTE
75 MCLVEIEKAPKVVAA
78 VEIEKAPKVVAACAM
99 NILTNSEKSKKAREG

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes

Protein Sequence

10 MLRIPVKRAL 20 IGLSKSPKGY 30 GKFLLYIHEI 40 FLEIYLCILK 50 YTACEKVGMQ 60 IPRFCYHERL 70 SVAGNCRMCL 80 VEIEKAPKVV 90 AACAMPVMKG 100 WNILTNSEKS 110 KKAREGVMEF 120 LLANHPLDCP 130 ICDQGGECDL 140 QDQSMMFGSD 150 RSRFLEGKRA 160 VEDKNIGPLV 170 KTIMTRCIQC 180 TRCIRFASEI 190 AGVDDLGTTG 200 RGNDMQVGTY 210 IEKMFMSELS 220 GNIIDICPVG 230 ALTSKPYAFT 240 ARPWETRKTE 250 SIDVMDAVGS 260 NIVVSTRTGE 270 VMRILPRMHE 280 DINEEWISDK 290 TRFAYDGLKR 300 QRLTEPMVRN 310 EKGLLTYTSW 320 EDALSRVAGM 330 LQSFEGKAVA 340 AIAGGLVDAE 350 ALVALKDLLN 360 KVDSDTLCTE 370 EIFPNEGAGT 380 DLRSNYLLNT 390 TIAGVEEADV 400 VLLVGTNPRF 410 EAPLFNARIR 420 KSWLHNDLKV 430 ALIGSPVDLT 440 YRYDHLGDSP 450 KILQDIASGN 460 HEFSKVLNAA 470 KKPMVVLGSS 480 ALQRDDGAAI 490 LAAVSSIAQK 500 IRVASGAAAE 510 WKVMNILHRI 520 ASQVAALDLG 530 YKPGVEAIRK 540 NPPKLLFLLG 550 ADGGCITRQD 560 LPKDCFIVYQ 570 GHHGDVGAPI 580 ADVILPGAAY 590 TEKSATYVNT 600 EGRAQQTKVA 610 VTPPGLARED 620 WKIIRALSEI 630 AGITLPYDTL 640 DQVRNRLGEV 650 SPNLVRYDDV 660 EEANYFQQAS 670 ELAKLVDQEF 680 LADPLVPPQL 690 TIKDFYMTDS 700 ISRASQTMAK 710 CVKAVTEGAQ AVEEPSIC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0045271 respiratory chain complex I
Molecular Function GO:0051537 2 iron, 2 sulfur cluster binding
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0008137 NADH dehydrogenase (ubiquinone) activity
Molecular Function GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process GO:0042773 ATP synthesis coupled electron transport
Biological Process GO:0032981 mitochondrial respiratory chain complex I assembly

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.