Search Results

Overview

Uniprot ID	A0A8I5ZY35
Protein Name	T-complex protein 1 subunit zeta
Gene Name	Cct6a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
10	AVKTLNPKAEVARAQ
199	EIMEMKHKSETDTSL
251	VNSGFFYKSAEEREK

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia

Protein Sequence

10 MAAVKTLNPK 20 AEVARAQAAL 30 AVNISAARGL 40 QDVLRTNLGP 50 KGTMKMLVSG 60 AGDIKLTKDG 70 NVLLHEMQIQ 80 HPTASLIAKV 90 ATAQDDITGD 100 GTTSNVLIIG 110 ELLKQADLYI 120 SEGLHPRIIT 130 EGFEAAKEKA 140 LQFLEQVKVS 150 KEMDRETLID 160 VARTSLRTKV 170 HAELADVLTE 180 AVVDSILAIR 190 KKDEPIDLFM 200 VEIMEMKHKS 210 ETDTSLIRGL 220 VLDHGARHPD 230 MKKRVENAYI 240 LTCNVSLEYE 250 KTEVNSGFFY 260 KSAEEREKLV 270 KAERKFIEDR 280 VKKIVELKKK 290 VCGDSDKGFV 300 VINQKGIDPF 310 SLDALAKEGI 320 VALRRAKRRN 330 MERLTLACGG 340 IALNSFDDLN 350 PDCLGHAGLV 360 YEYTLGEEKF 370 TFIEKCNNPR 380 SVTLLVKGPN 390 KHTLTQIKDA 400 IRDGLRAVKN 410 AIDDGCVVPG 420 AGAVEVALAE 430 ALIKYKPSVK 440 GRAQLGVQAF 450 ADALLIIPKV 460 LAQNSGFDLQ 470 ETLVKVQAEH 480 SESGQLVGVD 490 LNTGEPMVAA 500 EMGVWDNYCV 510 KKQLLHSCTV 520 IATNILLVDE 530 IMRAGMSSLK G

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone
Molecular Function	GO:0051082	unfolded protein binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.