Search Results
Overview
| Uniprot ID | A0A8I5ZYR5 |
|---|---|
| Protein Name | Glutathione S-transferase LANCL1 |
| Gene Name | Lancl1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | YHKMNSGKQAEDCIT |
Function
Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione
Protein Sequence
10
MAQRAFPNPY
20
ADYNKSLAEN
30
YFDSTGRLTP
40
EFSHRLTNKI
50
RELLQQMERG
60
LKSADPQDGT
70
GYTGWAGIAV
80
LYLHLHNVFG
90
DPAYLQMAHS
100
YVKHSLNCLS
110
RRSITFLCGD
120
AGPLAVAAVL
130
YHKMNSGKQA
140
EDCITRLIHL
150
NKIDPHVPNE
160
MLYGRIGYIF
170
ALLFVNKNFG
180
EEKIPQSHIQ
190
QICETILTSG
200
EKLSRKRNFT
210
TKSPLMYEWY
220
QEYYVGAAHG
230
LAGIYYYLMQ
240
PSLHVSQGKL
250
HSLVKPSVDF
260
VCQLKFPSGN
270
YPSCLDDTRD
280
LLVHWCHGAP
290
GVIYMLIQAY
300
KVFKEEHYLC
310
DAQQCADVIW
320
QYGLLKKGYG
330
LCHGAAGNAY
340
AFLALYNLTQ
350
DAKYLYRACK
360
FAEWCLDYGE
370
HGCRTPDTPF
380
SLFEGISHTQ
LSF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:0031179 | peptide modification |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.