Search Results
Overview
| Uniprot ID | A0A8I6A070 |
|---|---|
| Protein Name | Electron transfer flavoprotein subunit alpha |
| Gene Name | Etfa |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | VSGGRGLKSGENFKL |
| 69 | KVVQDLCKVAGVAKV |
Function
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism
Protein Sequence
10
MFRAAAPGQL
20
RRAASLLRFQ
30
STLVIAEHAN
40
DSLAPITLNT
50
ITAAGRLGGE
60
VSCLVAGTKC
70
DKVVQDLCKV
80
AGVAKVLVAQ
90
HDAYKGLLPE
100
ELTPLILETQ
110
KQFSYTHICA
120
GASAFGKNLL
130
PRVAAKLNVA
140
PVSDIIEIKS
150
PDTFVRTIYA
160
GNALCTVKCD
170
EKVKVFSVRG
180
TSFEAAAASG
190
GSASSEKAPS
200
SSSAGISEWL
210
DQKLTKSDRP
220
ELTGAKVVVS
230
GGRGLKSGEN
240
FKLLYDLADQ
250
LHAAVGASRA
260
AVDAGFVPND
270
MQVGQTGKIV
280
APELYIAVGI
290
SGAIQHLAGM
300
KDSKTIVAIN
310
KDPEAPIFQV
320
ADYGIVADLF
KVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045251 | electron transfer flavoprotein complex |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Biological Process | GO:0009063 | amino acid catabolic process |
| Biological Process | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process | GO:0022904 | respiratory electron transport chain |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.