Search Results
Overview
| Uniprot ID | A0A8I6A0K7 |
|---|---|
| Protein Name | Metastasis-associated protein MTA3 |
| Gene Name | Mta3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 558 | SLQTPTTKRMLTTPN |
Function
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6
Protein Sequence
10
MAANMYRVGD
20
YVYFENSSSN
30
PYLIRRIEEL
40
NKTASGNVEA
50
KVVCFYRRRD
60
ISNTLIMLAD
70
KHAKETEEES
80
ETTVEADLTE
90
KQKHQLKHRE
100
LFLSRQYESL
110
PATHIRGKCS
120
VALLNETESV
130
LSYLDKEDTF
140
FYSLVYDPSV
150
KTLLADKGEI
160
RVGPKYQADI
170
PDVLPEGDSD
180
EREQSKLEVK
190
VWDPNSPLTD
200
RQIDQFLVVA
210
RAVGTFARAL
220
DCSSSVRQPS
230
LHMSAAAASR
240
DITLFHAMDT
250
LYRHGYDLSS
260
AISVLVPLGG
270
PVLCRDEMEE
280
WSASEASLFE
290
EALEKYGKDF
300
NDIRQDFLPW
310
KSLTSIIEYY
320
YMWKTTDRYV
330
QQKRLKAAEA
340
ESKLKQVYIP
350
TYKPNPNQIS
360
SSNGKAGTVN
370
GAVGTPFQPQ
380
SALLGRACES
390
CYATQSHQWY
400
SWGPPNMQCR
410
LCATCWLYWK
420
KYGGLKMPTQ
430
TDEEKAPSPA
440
AEDPRVRSHL
450
SRQALQGMPV
460
RNTGSPKSAV
470
KTRQAFFLHT
480
TYFTKIARQV
490
CKNTLRLRQA
500
ARRPFVAINY
510
AAIRAEYADR
520
HAELSGSPLK
530
SKSTRKPLSC
540
IIGYLEIHPA
550
KKPNVIRSPP
560
SLQTPTTKRM
570
LTTPNHTSLS
580
ILGKRNYSHH
590
NGLDGSERWL
SR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016581 | NuRD complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.