Search Results
Overview
| Uniprot ID | A0A8I6A0P8 |
|---|---|
| Protein Name | Mitochondrial peptide methionine sulfoxide reductase |
| Gene Name | Msra |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | YTRNPTYKEVCSEKT |
| 183 | EYQKVLSKHGFGPIT |
Function
Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency
Protein Sequence
10
MLSASRRTLQ
20
LLSSSIPVRM
30
MGDSSSKVIS
40
AEEALPGRTE
50
SIPVAGTTAW
60
LLSMRVEPAH
70
SALPENVWGM
80
GCFWGAERKF
90
WLLKGVYSTQ
100
VGFAGGYTRN
110
PTYKEVCSEK
120
TGHAEVVRVV
130
YRPEHVSFEE
140
LLKVFWENHD
150
PTQGMRQGND
160
CGTQYRSAVY
170
PTSAVQMEAA
180
LKSKEEYQKV
190
LSKHGFGPIT
200
TDIREGQVFY
210
YAEDYHQQYL
220
SKNPDGYCGL
230
GGTGVSCPTA
IKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.