Search Results
Overview
| Uniprot ID | A0A8I6A0U2 |
|---|---|
| Protein Name | Thioredoxin-dependent peroxide reductase, mitochondrial |
| Gene Name | Prdx3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | ELSLDDFKGKYLVLF |
| 264 | ASKEYFEKVHQ**** |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength
Protein Sequence
10
MQQIASSRRR
20
RVQLFSLHFS
30
FQVARPASTI
40
FRSISASTVL
50
RPVASRRTCL
60
TDMLWSACPQ
70
AKFAFSTSSS
80
FHTPAVTQHA
90
PHFKGTAVVN
100
GEFKELSLDD
110
FKGKYLVLFF
120
YPLDFTFVCP
130
TEIVAFSDKA
140
NEFHDVNCEV
150
VAVSVDSHFS
160
HLAWINTPRK
170
NGGLGHMNIT
180
LLSDLTKQIS
190
RDYGVLLESA
200
GIALRGLFII
210
DPNGVIKHLS
220
VNDLPVGRSV
230
EETLRLVKAF
240
QFVETHGEVC
250
PANWTPESPT
260
IKPSPTASKE
YFEKVHQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0140824 | thioredoxin-dependent peroxiredoxin activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.