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Overview

Uniprot ID	A0A8I6A163
Protein Name	Unconventional myosin-XVIIIa
Gene Name	Myo18a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
743	AIFKHQLKGGTLQRS

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking. Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages. Strongly enhances natural killer cell cytotoxicity

Protein Sequence

10 MHSLWLDNDP 20 QSQKLQGGGR 30 ARGVSQPEAK 40 FRAELIPEPS 50 VPDTLRGNQH 60 FQCLTLDSCL 70 GPQTQATGER 80 TNLELVKEED 90 KSVPKPGPPG 100 KEEGALETSS 110 KDSSAPPRSP 120 QPATSPVPSE 130 TSQRVKSPEP 140 TLTMNGLEAA 150 PAEGPNEEAQ 160 SLSRKRVANA 170 VRKVVSKVLP 180 GEEPGNAKEP 190 PGRGAKSPEH 200 PARGKKGEKA 210 ASSPKPPPPP 220 PPPPPPPAPP 230 KPEAKKEAAK 240 DELSLGLRSL 250 MSKGRGKDHK 260 SRSKQPPGKG 270 EKAPSQEPAP 280 SGESGSPDMV 290 DSPKKAGSPS 300 PAQELAEPNL 310 ASPKLTPSGE 320 QQAKSPASDV 330 QQETGADPGV 340 RLSPAEEAHQ 350 RLERIFTAPL 360 DPVAASPAHS 370 QAKTEEQIAA 380 EEAWYETEKV 390 WLVHRDGFSL 400 ASQLKSEELS 410 LPEGKVRVKL 420 DHDGAILDVD 430 EDDVEKANAP 440 SCDRLEDLAS 450 LVYLNESSVL 460 HTLRQRYGAS 470 LLHTYAGPSL 480 LVLSPRGAPA 490 VYSEKVMHMF 500 KGCRREDMAP 510 HIYAVAQTAY 520 RAMLMSRQDQ 530 SIVLLGSSGS 540 GKTTSSQHLV 550 QYLATIAGTS 560 GNKVFSVEKW 570 QALATLLEAF 580 GNSPTIMNGS 590 ATRFSQILSL 600 DFDQAGQVAS 610 ASVQTMLLEK 620 LRVARRPASE 630 ATFNVFYYLL 640 ACGDSTLRTE 650 LHLNHLAENN 660 VFGIVPLSKP 670 EEKQRAAQQF 680 SKLQTAMKVL 690 AISPEEQKAC 700 WLILASIYHL 710 GAAGATKGGR 720 KQFARHEWAQ 730 KAAYLLGCSL 740 EELSSAIFKH 750 QLKGGTLQRS 760 TSFRQGPEES 770 GLGEGTGTKL 780 SALECLEGMA 790 SGLYSELFTL 800 LISLVNRALK 810 SSQHSLCSMM 820 IVDTPGFQNP 830 EWGGSARGAS 840 FEELCHNYAQ 850 DRLQKLFHER 860 TFLQELERYK 870 EDNIELAFDD 880 LEPVTDDSVA 890 AVDQASHQSL 900 VRSLAHADEA 910 RGLLWLLEEE 920 ALVPGATEDT 930 LLDRLFSYYG 940 PQEGDKKGQS 950 PLLRSSKPRH 960 FLLGHSHGTN 970 WVEYNVTGWL 980 NYTKQNPATQ 990 NAPRLLQDSQ 1000 KKIISNLFLG 1010 RAGSATVLSG 1020 SIAGLEGGSQ 1030 LALRRATSMR 1040 KTFTTGMAAV 1050 KKKSLCIQIK 1060 LQVDALIDTI 1070 KRSKMHFVHC 1080 FLPVAEGWPG 1090 EPRSASSRRV 1100 SSSSELDLPP 1110 GDPCEAGLLQ 1120 LDVSLLRAQL 1130 RGSRLLDAIR 1140 MYRQGYPDHM 1150 VFSEFRRRFD 1160 VLAPHLTKKH 1170 GRNYIMVDEK 1180 RAVEELLESL 1190 DLEKSSCCMG 1200 LSRVFFRAGT 1210 LARLEEQRDE 1220 ETSRHLTLFQ 1230 AACRGYLARQ 1240 HFKKRKIQDL 1250 AIRCVQKNIK 1260 KNKGVKDWPW 1270 WKLFTTVRPL 1280 IQVQLSEEQI 1290 RNKDEEIQQL 1300 RNKLEKVEKE 1310 RNELRLNSDR 1320 LETRISELTS 1330 ELTDERNTGE 1340 SASQLLDAET 1350 AERLRTEKEM 1360 KELQTQYDAL 1370 KKQMEAMDME 1380 VMEARLIRAA 1390 EINGEVDDDD 1400 AGGEWRLKYE 1410 RAVREVDFTK 1420 KRLQQELEDK 1430 MEVEQQNRRQ 1440 LERRLGDLQA 1450 DSDESQRALQ 1460 QLKKKCQRLT 1470 AELQDTKLHL 1480 EGQQVRNHEL 1490 EKKQRRFDSE 1500 LSQAHEETQR 1510 EKLQREKLQR 1520 EKDMLLAEAF 1530 SLKQQMEEKD 1540 LDIAGFTQKV 1550 VSLEAELQDI 1560 SSQESKDEAS 1570 LAKVKKQLRD 1580 LEAKVKDQEE 1590 ELDEQAGSIQ 1600 MLEQAKLRLE 1610 MEMERMRQTH 1620 SKEMESRDEE 1630 VEEARQSCQK 1640 KLRQMEVQLE 1650 EEYEDKQKAL 1660 REKRELESKL 1670 STLSDQVNQR 1680 DFESEKRLRK 1690 DLKRTKALLA 1700 DAQIMLDHLK 1710 NNAPSKREIA 1720 QLKNQLEESE 1730 FTCAAAVKAR 1740 KAMEVEMEDL 1750 HLQIDDIAKA 1760 KTALEEQLSR 1770 LQREKNEIQN 1780 RLEEDQEDMN 1790 ELMKKHKAAV 1800 AQASRDMAQM 1810 NDLQAQLEES 1820 NKEKQELQEK 1830 LQALQSQVEF 1840 LEQSMVDKSL 1850 VSRQEAKIRE 1860 LETRLEFEKT 1870 QVKRLESMAS 1880 RLKENMEKLT 1890 EERDQRAAAE 1900 NREKEQNKRL 1910 QRQLRDTKEE 1920 MSELARKEAE 1930 ASRKKHELEM 1940 DLESLEAANQ 1950 SLQADLKLAF 1960 KRIGDLQAAI 1970 EDEMESDENE 1980 DLINSLQDMV 1990 TKYQKRKNKL 2000 EGDSDVDSEL 2010 EDRVDGVKSW 2020 LSKNKGPSKA 2030 PSDDGSLKSS 2040 RTALNSLPKE 2050 GKGPEERPSS 2060 VLSSLSYRKR 2070 LTLKDSIGGT 2080 GDQDSLLTTL 2090 SERATSPERP 2100 PRKARVGPRE 2110 EPDQAQGRRC 2120 EELDDCSSIF 2130 SVAGSRTGRG 2140 LEKRWGSDFD 2150 RASTVSAPVS 2160 RASSATRGSG 2170 EDRARSSMSF 2180 SLSGSPSSRR 2190 STSRLDSLSR 2200 TVSPSWNRAS 2210 GLSRESPESR 2220 LSLGQSCLDE 2230 WDDGASVALS 2240 EAHSQFSHPS 2250 LARSLSVPPQ 2260 PRGSSSASAS 2270 VTEGSSIRPV 2280 SRHSYLDPDL 2290 EAAINEVLSY 2300 KPVPFQRSSL 2310 EPDSEDDDRK 2320 SIQSAQSAQL 2330 EYPERDTSIR 2340 RSASAADVSS 2350 RSGRKSRSKH 2360 RSKRSSPSSS 2370 SSSSSSEGSS 2380 EHKRRKKGRS 2390 RKSKKKSKSR 2400 RKKTETESDS 2410 SSSSSGSTVS 2420 GHSRSSVKKG 2430 PTADIEEVGQ 2440 TPRRSKKEEK 2450 QRKKEVDSLM 2460 MRYLYRPESD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0016459	myosin complex
Cellular Component	GO:0005802	trans-Golgi network
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0043531	ADP binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003774	cytoskeletal motor activity
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0090164	asymmetric Golgi ribbon formation
Biological Process	GO:0016477	cell migration
Biological Process	GO:0048194	Golgi vesicle budding
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1903028	positive regulation of opsonization
Biological Process	GO:0050714	positive regulation of protein secretion
Biological Process	GO:0043030	regulation of macrophage activation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.