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Overview

Uniprot ID	A0A8I6A171
Protein Name	Active breakpoint cluster region-related protein
Gene Name	Abr
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
572	YDKTKVNKDNNEIVD

Function

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity

Protein Sequence

10 MRSRRGPPRA 20 RRPCHTSTSH 30 PPCRPSSALA 40 ARAVGRASHP 50 PHLRGWHLGT 60 PNRVIQWRVN 70 IVILVQVQRH 80 ENQVEAGKGL 90 EMRKLVLSGF 100 LASEEIYINQ 110 LEALLLPMKP 120 LKATATTSQP 130 VLTIQQIETI 140 FYKIQDIYEI 150 HKEFYDNLCP 160 KVQQWDSQVT 170 MGHLFQKLAS 180 QLGVYKAFVD 190 NYKVALETAE 200 KCSQSNNQFQ 210 KISEELKVKG 220 PKDSKDSHTS 230 VTMEALLYKP 240 IDRVTRSTLV 250 LHDLLKHTPV 260 DHPDYPLLQD 270 ALRISQNFLS 280 SINEDIDPRR 290 TAVTTPKGET 300 RQLVKDGFLV 310 EMSESSRKLR 320 HVFLFTDVLL 330 CAKLKKTSAG 340 KHQQYDCKWY 350 IPLADLVFPS 360 PEESEASPQV 370 HPFPDHELED 380 MKVKISALKS 390 EIQKEKANKG 400 QSRAIERLKK 410 KMFENEFLLL 420 LNSPTIPFRI 430 HNRNGKSYLF 440 LLSSDYERSE 450 WREAIQKLQK 460 KDLQAFVLSS 470 VELQVLTGSC 480 FKLRTVHNIP 490 VTSNKDDDES 500 PGLYGFLHVI 510 VHSAKGFKQS 520 ANLYCTLEVD 530 SFGYFVSKAK 540 TRVFRDTTEP 550 KWDEEFEIEL 560 EGSQSLRILC 570 YEKCYDKTKV 580 NKDNNEIVDK 590 IMGKGQIQLD 600 PQTVESKNWH 610 TDVIEMNGIK 620 VEFSMKFTSR 630 DMSLKRTPSK 640 KQTGVFGVKI 650 SVVTKRERSK 660 VPYIVRQCIE 670 EVEKRGIEEV 680 GIYRISGVAT 690 DIQALKAVFD 700 ANNKDILLML 710 SDMDINAIAG 720 TLKLYFRELP 730 EPLLTDRLYP 740 AFMEGIALSD 750 PAAKENCMMH 760 LLRSLPDPNL 770 ITFLFLLEHL 780 KRVAEKEPIN 790 KMSLHNLATV 800 FGPTLLRPSE 810 VESKAHLTSA 820 ADIWSHDVMA 830 QVQVLLYYLQ 840 HPPISFAELK 850 RNTLYFSTDV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0099092	postsynaptic density, intracellular component
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Biological Process	GO:0035556	intracellular signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.