Search Results

Overview

Uniprot IDA0A8I6A1X3
Protein NameKinesin-like protein KIF21A
Gene NameKif21a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
562 KKKSVAGKENNADPD
832 QVRPMSDKVAGKVTR

Function

Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex

Protein Sequence

10 MLGAADESSV 20 RVAVRIRPQL 30 AKEKIEGCHI 40 CTSVTPGEPQ 50 VFLGKDKAFT 60 FDYVFDIDSQ 70 QEQIYTQCIE 80 KLIEGCFEGY 90 NATVFAYGQT 100 GAGKTYTMGT 110 GFDVNIMEEE 120 QGIISRAVKH 130 LFKSIEEKKT 140 SAIKNGVPPP 150 EFKVNAQFLE 160 LYNEEVLDLF 170 DTTRDIDAKN 180 KKSNIRIHED 190 STGGIYTVGV 200 TTRTVNTEPE 210 MMQCLKLGAL 220 SRTTASTQMN 230 VQSSRSHAIF 240 TIHVCQTRVC 250 PQTDAENVTD 260 NKMVSESPQM 270 NEFETLTAKF 280 HFVDLAGSER 290 LKRTGATGER 300 AKEGISINCG 310 LLALGNVISA 320 LGDKSKRATH 330 VPYRDSKLTR 340 LLQDSLGGNS 350 QTIMIACVSP 360 SDRDFMETLN 370 TLKYANRARN 380 IKNKVMVNQD 390 RASQQINALR 400 SEITRLQMEL 410 MEYKTGKRII 420 DEEGVESIND 430 MFHENAMLQT 440 ENNNLRVRIK 450 AMQETVDALR 460 ARITQLVSEQ 470 ANQVLARAGE 480 GNEEISNMIH 490 SYIKEIEDLR 500 AKLLESEAVN 510 ENLRKSLTRA 520 TARSPFFSAS 530 SAFSSTILSS 540 DKETIEIIDL 550 AKKDLEKLKR 560 KEKRKKKSVA 570 GKENNADPDQ 580 EKKEEKGVSE 590 KESSEVDVDE 600 NQEASDHEDE 610 EDEEEEDEEE 620 DDIEGEESSD 630 ESDSESDEKA 640 NYQADLANIT 650 CEIAIKQKLI 660 DELENSQKRL 670 QTLKKQYEEK 680 LMMLQHKIRD 690 TQLERDQVLQ 700 NLGSVESYSE 710 EKAKKVKCEY 720 EKKLHAMNKE 730 LQRLQTAQKE 740 HARLLKNQSQ 750 YEKQLKKLQQ 760 DVTEMKKTKV 770 RLMKQMKEEQ 780 EKARLTESRR 790 NREIAQLKKD 800 QRKRDHQLRL 810 LEAQKRNQEV 820 VLRRKTEEVT 830 ALRRQVRPMS 840 DKVAGKVTRK 850 LSSSESPTPD 860 AGSSVTSGEA 870 DASRPGTQQK 880 MRIPVARVQA 890 LPTPTTNGTR 900 KRYQRKGFTG 910 RVFTSKTARM 920 KWQLLERRVT 930 EIIMQKMTIS 940 NMEADMNRLL 950 RQREELTKRR 960 EKLSKRREKI 970 AKESGEGDKN 980 LVNISEEMES 990 LTANIDYIND 1000 SIADCQANIM 1010 QMEEAKEEGE 1020 TLDVTAVINA 1030 CTLTEARYLL 1040 DHFLSMGINK 1050 GLQAAQKEAQ 1060 IKVLEGRLKQ 1070 TEITSATQNQ 1080 LLFHMLKEKA 1090 ELNPELDALL 1100 GNALQDLDSA 1110 PLEDEEDSSE 1120 EDGPLHSPGS 1130 EGSTLSSDLM 1140 KLCGEVKPKN 1150 KARRRTTTQM 1160 ELLYADSSEV 1170 ASDTSAGDAS 1180 LPGPLTPVAE 1190 GQETGMNTET 1200 SVPSARDKEL 1210 LPPSGLPPKI 1220 GSISRQPSVS 1230 EKKVPEPSPV 1240 TRRKAYEKAD 1250 KAKTKEQKHS 1260 DSGASETSLS 1270 PPSSPPSRPR 1280 NELNVFNRLT 1290 VSQGSAPVQQ 1300 DKSDESDPSL 1310 SEVHSRSSRR 1320 GIINPFPACR 1330 GIRASFLQCV 1340 HVAEGHTKAV 1350 LCVDSTDDLL 1360 FTGSKDRTCK 1370 VWNLVTGQEI 1380 MSLGVHPNNV 1390 VSVKYCNYTS 1400 LVFTVSTSYI 1410 KVWDIRESAK 1420 CIRTLTSSGQ 1430 VTLGEACSAS 1440 TSRTVAIPSG 1450 ESQINQIALN 1460 PTGTFLYAAS 1470 GNAVRMWDLK 1480 RFQSTGKLTG 1490 HLGPVMCLTV 1500 DQISNGQDLI 1510 ITGSKDHYIK 1520 MFDVTEGALG 1530 TVSPTHNFEP 1540 PHYDGIEALA 1550 IQGDNLFSGS 1560 RDNGIKKWDL 1570 AQKGLLQQVP 1580 NAHKDWVCAL 1590 GLVPGHPILL 1600 SGCRGGILKL 1610 WNVDTFVPVG 1620 EMRGHDSPIN 1630 AISVNSTHVF 1640 TAADDRTVRI 1650 WKAHNLQDGQ 1660 ISDTGDPGED STSN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0030426 growth cone
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Biological Process GO:0007018 microtubule-based movement

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.