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Overview

Uniprot ID	A0A8I6A206
Protein Name	Nucleolin
Gene Name	Ncl
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
43	IPQKKGKKATTTPAK

Function

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats

Protein Sequence

10 MGRKLLITHL 20 LDMTFPKIGV 30 HSETLSQDSF 40 YGHVVIPQKK 50 GKKATTTPAK 60 KVVVSQTKKA 70 AVPTPAKKAA 80 VTPGKKAAAT 90 PAKKAVTPAK 100 VVPTPGKKGA 110 AQAKALVPTP 120 GKKGAVTPAK 130 GAKNGKNAKK 140 EDSDEDEDEE 150 DEDDSDEDED 160 EEDEFEPPVV 170 KGVKPAKAAP 180 AAPASEDEDE 190 EDDDDEEDDD 200 DDDEEEEEED 210 DSEEEVMEIT 220 PAKGKKTPAK 230 VVPVKAKSVA 240 EEEEDDEDDE 250 DEEEDEDEED 260 EEDDEDEDEE 270 EEEEPVKAAP 280 GKRKKEMTKQ 290 KEAPEAKKQK 300 IEGSEPTTPF 310 NLFIGNLNPN 320 KSVAELKVAI 330 SELFAKNDLA 340 AVDVRTGTNR 350 KFGYVDFESA 360 EDLEKALELT 370 GLKVFGNEIK 380 LEKPKGRDSK 390 KVRAARTLLA 400 KNLSFNITED 410 ELKEVFEDAV 420 EIRLVSQDGR 430 SKGIAYIEFK 440 SEADAEKNLE 450 EKQGAEIDGR 460 SVSLYYTGEK 470 GQRQERTGKN 480 STWSGESKTL 490 VLSNLSYSAT 500 EETLQEVFEK 510 ATFIKVPQNP 520 HGKSKGYAFI 530 EFASFEDAKE 540 ALNSCNKMEI 550 EGRTIRLELQ 560 GPRGSPNARS 570 QPSKTLFVKG 580 LSEDTTEETL 590 KESFEGSVRA 600 RIVTDRETGS 610 SKGFGFVDFN 620 SEEDAKAAKE 630 AMEDGEIDGN 640 KVTLDWAKPK 650 GEGGFGGRGG 660 GRGGFGGRGG 670 GRGGRGGFGG 680 RGRGGFGGRG 690 GFRGGRGGGG 700 DFKPQGKKTK FE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003723	RNA binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.