Overview
| Uniprot ID | A0A8I6A2K6 |
|---|
| Protein Name | - |
|---|
| Gene Name | Stam |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 160 |
ASPALVAKDPGTVAT |
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes
Protein Sequence
10
MESVRNWQNV
20
LEKATSELNT
30
AEDWGLILDI
40
CDKVGQSRTG
50
PKDCLRSIMR
60
RVNHKDPHVA
70
MQALTLLGAC
80
VSNCGKIFHL
90
EVCSRDFASE
100
VSNVLNKGHP
110
KVCEKLKALM
120
VEWTDEFKND
130
PQLSLISAMI
140
KNLKEQGVTF
150
PAIGSQAAEQ
160
AKASPALVAK
170
DPGTVATKKE
180
EEDLAKAIEL
190
SLKEQRQQAA
200
PLSTLYPSTS
210
SLLTNHQHEG
220
RKVRAVYDFE
230
AAEDNELTFK
240
AGEVITVLDD
250
SDPNWWKGET
260
HQGMGLFPSN
270
FVTADLTAEP
280
EMIKTEKKTV
290
QFSDDVQIET
300
IEPEPEPEPA
310
FIDEDKMDQL
320
LQMLQSTDPS
330
DNQPDLPELL
340
HLEAMCHQMG
350
PLIDEKLEDI
360
DRKHSELSEL
370
NVKVMEALSL
380
YTKLMNEDPV
390
YSVYAKSQSQ
400
QYYVQASGVS
410
APQVYPGPAQ
420
SGAYLVAGNA
430
QMTHLQSYSL
440
PPEQLASISQ
450
GAVPPSATPA
460
LPNQQAQASY
470
PNAMVSSVQG
480
NSYPSQASIY
490
SPAAAAAAVA
500
VTAVPVPADV
510
TIYQNPGPNM
520
SQVPNYTLTS
530
STLPHTGGSQ
540
QPPQPQQAYS
QKALL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Biological Process |
GO:0016236 |
macroautophagy |
| Biological Process |
GO:0036258 |
multivesicular body assembly |
| Biological Process |
GO:0015031 |
protein transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.