Overview
| Uniprot ID | A0A8I6A2M9 |
|---|
| Protein Name | BAR/IMD domain-containing adapter protein 2 |
|---|
| Gene Name | Baiap2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 122 |
YLSAALKKYQTEQRS |
| 160 |
NPQKYSDKELQYIDA |
| 351 |
VRKSVTPKNSYATTE |
| 36 |
RNFIAMGKNYEKALA |
Function
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions
Protein Sequence
10
MSLSRSEEMH
20
RLTENVYKTI
30
MEQFNPSLRN
40
FIAMGKNYEK
50
ALAGVTFAAK
60
GYFDALVKMG
70
ELASESQGSK
80
ELGDVLFQMA
90
EVHRQIQNQL
100
EEMLKAFHNE
110
LLTQLEQKVE
120
LDSRYLSAAL
130
KKYQTEQRSK
140
GDALDKCQAE
150
LKKLRKKSQG
160
SKNPQKYSDK
170
ELQYIDAISN
180
KQGELENYVS
190
DGYKTALTEE
200
RRRFCFLVEK
210
QCAVAKNSAA
220
YHSKGKELLA
230
QKLPLWQQAC
240
ADPNKIPDRA
250
AQLMQQMANS
260
NGSILPSALS
270
ASKSNLVISD
280
PIPGAKPLPV
290
PPELAPFVGR
300
MSAQENVPVM
310
NGVAGADSED
320
YNPWADRKAA
330
QPKSLSPPQS
340
QSKLSDSYSN
350
TLPVRKSVTP
360
KNSYATTENK
370
TLPRSSSMAA
380
GLERNGRMRV
390
KAIFSHAAGD
400
NSTLLSFKEG
410
DLITLLVPEA
420
RDGWHYGESE
430
KTKMRGWFPF
440
SYTRVLDSDG
450
SDRLHMSLQQ
460
GKSSSTGNLL
470
DKDDLALPPP
480
DYGTSSRAFP
490
SQTAGTFKQR
500
PYSVAVPAFS
510
QGLDDYGARS
520
VSSADVEVAR
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0030175 |
filopodium |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0001726 |
ruffle |
| Molecular Function |
GO:0008093 |
cytoskeletal anchor activity |
| Biological Process |
GO:0030182 |
neuron differentiation |
| Biological Process |
GO:0007009 |
plasma membrane organization |
| Biological Process |
GO:0032956 |
regulation of actin cytoskeleton organization |
| Biological Process |
GO:0022604 |
regulation of cell morphogenesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.