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Overview

Uniprot ID	A0A8I6A2T3
Protein Name	Alpha-1,4 glucan phosphorylase
Gene Name	Pygm
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
29	VENVSDLKKNFNRHL
78	TQQHYYEKDPKRIYY

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MSRPLSDQDK 20 RKQISVRGLA 30 GVENVSDLKK 40 NFNRHLHFTL 50 VKDRNVATPR 60 DYYFALAHTV 70 RDHLVGRWIR 80 TQQHYYEKDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLALENACD 120 EATYQVGEAL 130 KLVGVGQRGF 140 LPCFLDSMAT 150 LGLAAYGYGI 160 RYEFGIFNQK 170 ICGGWQMEEA 180 DDWLRYGNPW 190 EKARPEFTLP 200 VHFYGRVEHT 210 SQGAKWVDTQ 220 VVLAMPYDTP 230 VPGYRNNVVN 240 TMRLWSAKAP 250 NDFNLKDFNV 260 GGYIQAVLDR 270 NLAENISRVL 280 YPNDNFFEGK 290 ELRLKQEYFV 300 VAATLQDIIR 310 RFKSSKFGCR 320 DPVRTNFDAF 330 PDKVAIQLND 340 THPSLAIPEL 350 MRILVDLERL 360 DWDKAWDVTV 370 KTCAYTNHTV 380 LPEALERWPV 390 HLMETLLPRH 400 LQIIYEINQR 410 FLNRVAAAFP 420 GDVDRLRRMS 430 LVEEGAVKRI 440 NMAHLCIAGS 450 HAVNGVARIH 460 SEILKKTIFK 470 DFYELEPHKF 480 QNKTNGITPR 490 RWLVLCNPGL 500 AEVIAERIGE 510 EYISDLDQLR 520 KLLSYVDDEA 530 FIRDVAKVKQ 540 ENKLKFSAYL 550 EREYKVHINP 560 NSLFDVQVKR 570 IHEYKRQLLN 580 CLHIITLYNR 590 IKREPNRFMV 600 PRTIMIGGKA 610 APGYHMAKMI 620 IKLITAIGDV 630 VNHDPAVGDR 640 LRVIFLENYR 650 VSLAEKVIPA 660 ADLSEQISTA 670 GTEASGTGNM 680 KFMLNGALTI 690 GTMDGANVEM 700 AEEAGEDNFF 710 IFGMRVEDVE 720 RLDQRGYNAQ 730 EYYDRIPELR 740 QIIEQLSSGF 750 FSPKQPDLFK 760 DIVNMLMHHD 770 RFKVFADYEE 780 YIKCQDKVSE 790 LYKNPREWTR 800 MVIRNIATSG 810 KFSSDRTIAQ 820 YAREIWGVEP 830 SRQRLPAPDE KI

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0008184	glycogen phosphorylase activity
Molecular Function	GO:0030170	pyridoxal phosphate binding
Biological Process	GO:0005980	glycogen catabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.