Overview
| Uniprot ID | A0A8I6A3B7 |
|---|
| Protein Name | F-actin-capping protein subunit beta |
|---|
| Gene Name | Capzb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 265 |
LNEIYFGKTKDIVNG |
| 282 |
SVQTFADKSKQEALK |
| 284 |
QTFADKSKQEALKND |
| 297 |
NDLVEALKRKQQC** |
| 87 |
ARDKVVGKDYLLCDY |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MMHPSRRSLP
20
FPLNCQLVRV
30
GTADYGGAAD
40
QSDQQLDCAL
50
DLMRRLPPQQ
60
IEKNLSDLID
70
LVPSLCEDLL
80
SSVDQPLKIA
90
RDKVVGKDYL
100
LCDYNRDGDS
110
YRSPWSNKYD
120
PPLEDGAMPS
130
ARLRKLEVEA
140
NNAFDQYRDL
150
YFEGGVSSVY
160
LWDLDHGFAG
170
VILIKKAGDG
180
SKKIKGCWDS
190
IHVVEVQEKS
200
SGRTAHYKLT
210
STVMLWLQTN
220
KSGSGTMNLG
230
GSLTRQMEKD
240
ETVSDCSPHI
250
ANIGRLVEDM
260
ENKIRSTLNE
270
IYFGKTKDIV
280
NGLRSVQTFA
290
DKSKQEALKN
300
DLVEALKRKQ
QC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.