Search Results
Overview
| Uniprot ID | A0A8I6A3D0 |
|---|---|
| Protein Name | Isovaleryl-CoA dehydrogenase, mitochondrial |
| Gene Name | Ivd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 239 | MPGFSTSKKLDKLGM |
| 56 | QLRHTISKFVQENLA |
| 76 | IDQSNDFKNLREFWK |
Function
A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor
Protein Sequence
10
MATAVRLLGR
20
RVSSWRLRPL
30
PSPLAVPQRA
40
HSMLPVDDDI
50
NGLNEEQKQL
60
RHTISKFVQE
70
NLAPKAQEID
80
QSNDFKNLRE
90
FWKQLGSLGV
100
LGITAPVQYG
110
GSGLGYLEHV
120
LVMEEISRAS
130
AAVGLSYGAH
140
SNLCINQIVR
150
NGNEAQKEKY
160
LPKLISGEFI
170
GALAMSEPNA
180
GSDVVSMRLK
190
AEKKGDHYVL
200
NGNKFWITNG
210
PDADVLVVYA
220
KTDLTAVPAS
230
RGITAFIVEK
240
DMPGFSTSKK
250
LDKLGMRGSN
260
TCELVFEDCK
270
VPAANILSQE
280
SKGVYVLMSG
290
LDLERLVLAG
300
GPLGIMQAVL
310
DHTIPYLHVR
320
EAFGQKIGQF
330
QLMQGKMADM
340
YTRLMACRQY
350
VYNVARACGN
360
GYINDFPMGR
370
FLRDAKLYEI
380
GGGTSEVRRL
390
VIGRAFNADF
R
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008470 | 3-methylbutanoyl-CoA dehydrogenase activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Biological Process | GO:0006552 | L-leucine catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.