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Overview

Uniprot IDA0A8I6A3Q6
Protein NameActive breakpoint cluster region-related protein
Gene NameAbr
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
907 YDKTKVNKDNNEIVD

Function

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity

Protein Sequence

10 MWDPQEFERH 20 WQAEFPGEEA 30 PVMKLESVPD 40 MERELERCKL 50 NLKRLQQVLA 60 EEKFKVWYLQ 70 AALAGERMDL 80 PRGPPEGGDG 90 GGCGSGTGSR 100 GASVEEQEPA 110 GAVCAPPPHN 120 KEGASSRDSD 130 SPGPTLLDSE 140 VATSAEPSPF 150 MCLDLPAWPG 160 AVEGGGAVRS 170 LTAAIHQQLV 180 QPRLLFRLRE 190 DCVPPAPDGT 200 GSPIPGDQRS 210 SETRAGRGSE 220 EGEPDASGGD 230 DGGDCSDHDF 240 EIVDLNEKFV 250 LGHLLMAPCR 260 FGTRDEAEKP 270 ARPCSPHRWM 280 HLISGGWRHH 290 RRRSRDLEQL 300 EAEDESPRRG 310 AREHLAQWGR 320 KRFLRVPDRD 330 SPSHSSPERG 340 SDCSHNSSDH 350 EDGFSADFSY 360 GAEDYDAEGH 370 EEQKGPPEGS 380 ETMPYIDESP 390 TMSPQLSARS 400 QGGGESISPT 410 PPEGLAPGVE 420 AGKGLEMRKL 430 VLSGFLASEE 440 IYINQLEALL 450 LPMKPLKATA 460 TTSQPVLTIQ 470 QIETIFYKIQ 480 DIYEIHKEFY 490 DNLCPKVQQW 500 DSQVTMGHLF 510 QKLASQLGVY 520 KAFVDNYKVA 530 LETAEKCSQS 540 NNQFQKISEE 550 LKVKGPKDSK 560 DSHTSVTMEA 570 LLYKPIDRVT 580 RSTLVLHDLL 590 KHTPVDHPDY 600 PLLQDALRIS 610 QNFLSSINED 620 IDPRRTAVTT 630 PKGETRQLVK 640 DGFLVEMSES 650 SRKLRHVFLF 660 TDVLLCAKLK 670 KTSAGKHQQY 680 DCKWYIPLAD 690 LVFPSPEESE 700 ASPQVHPFPD 710 HELEDMKVKI 720 SALKSEIQKE 730 KANKGQSRAI 740 ERLKKKMFEN 750 EFLLLLNSPT 760 IPFRIHNRNG 770 KSYLFLLSSD 780 YERSEWREAI 790 QKLQKKDLQA 800 FVLSSVELQV 810 LTGSCFKLRT 820 VHNIPVTSNK 830 DDDESPGLYG 840 FLHVIVHSAK 850 GFKQSANLYC 860 TLEVDSFGYF 870 VSKAKTRVFR 880 DTTEPKWDEE 890 FEIELEGSQS 900 LRILCYEKCY 910 DKTKVNKDNN 920 EIVDKIMGKG 930 QIQLDPQTVE 940 SKNWHTDVIE 950 MNGIKVEFSM 960 KFTSRDMSLK 970 RTPSKKQTGV 980 FGVKISVVTK 990 RERSKVPYIV 1000 RQCIEEVEKR 1010 GIEEVGIYRI 1020 SGVATDIQAL 1030 KAVFDANNKD 1040 ILLMLSDMDI 1050 NAIAGTLKLY 1060 FRELPEPLLT 1070 DRLYPAFMEG 1080 IALSDPAAKE 1090 NCMMHLLRSL 1100 PDPNLITFLF 1110 LLEHLKRVAE 1120 KEPINKMSLH 1130 NLATVFGPTL 1140 LRPSEVESKA 1150 HLTSAADIWS 1160 HDVMAQVQVL 1170 LYYLQHPPIS 1180 FAELKRNTLY FSTDV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0099092 postsynaptic density, intracellular component
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0035556 intracellular signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.