Search Results

Overview

Uniprot ID	A0A8I6A3R3
Protein Name	Threonine--tRNA ligase, mitochondrial
Gene Name	Tars2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
61	RLASMTQKKARTIKI
67	QKKARTIKISLPEGQ

Function

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain

Protein Sequence

10 MGLCLRWRRL 20 GFPLPGFRRC 30 ELHTVREAPI 40 PTPPHWLAER 50 FGLFEELWTA 60 QVKRLASMTQ 70 KKARTIKISL 80 PEGQKVDAVA 90 WNTTPYQLAQ 100 QISSTLADTA 110 VAAEVNGELY 120 DLDRPLETDC 130 HLRFLTFDSP 140 EGKAVFWRSS 150 AHVLGAAAEQ 160 HLGAVLCRGP 170 STESGFYLDF 180 FLGKERTVRS 190 TELPTLERIC 200 QEIITAAQPF 210 RRLEASRGQL 220 RQLFKDNHFK 230 LHVIEEKVTG 240 TTATVYGCGM 250 SVDLCQGPHL 260 RHTGQIGALK 270 LLTNSSALWR 280 SSEAPETLQR 290 VSGISFPKAE 300 LLRNWEARRE 310 EAELRDHRRI 320 GKEQELFFFH 330 ELSPGSCFFL 340 PRGTRIYNAL 350 VAFIRAEYAR 360 RGFSEVKTPT 370 LFSTKLWEQS 380 GHWEHYRAHM 390 FSLKPPGTDG 400 VDSSQSGHPA 410 RCPKDTLALK 420 PMNCPAHCLM 430 FAHRPRSWRE 440 LPVRLADFGV 450 LHRAEASGSL 460 GGLTRLWRFQ 470 QDDAHIFCAP 480 SQLEAEIRGC 490 LDFLRSVYSV 500 LGFSFHLALS 510 TRPPGFLGEP 520 HLWDQAEKID 530 VHLHDALGRP 540 HQCGTIQLDF 550 QLPLRFDLQY 560 KGPAGAPECP 570 VLIHRAVLGS 580 VERLLGVLAE 590 SCGGRWPLWL 600 SPFQVVVIPV 610 RTEQEDYARQ 620 VQQCLQAAGL 630 VSDLDADCGL 640 TLSRRVRRAQ 650 LAHYNFQFVV 660 GQREQSQMSV 670 NVRTRDNRQL 680 GERGLAESVQ 690 RLLELQDARV PNAEELF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004829	threonine-tRNA ligase activity
Biological Process	GO:0006435	threonyl-tRNA aminoacylation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.