Overview
| Uniprot ID | A0A8I6A4F6 |
|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Gene Name | Prkacb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 131 |
KQKVVKLKQIEHTLN |
| 140 |
IEHTLNEKRILQAVE |
| 327 |
LLQVDLTKRFGNLKN |
| 71 |
KEFLAKAKEDFLRKW |
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR
Protein Sequence
10
MAAHKELSFG
20
QHTGTPTALQ
30
KLEGFASRLF
40
HRHSKGTAQD
50
QKAALEEEGL
60
QASEHTASWD
70
KPMKEFLAKA
80
KEDFLRKWEN
90
PPPSNAGLED
100
FERKKTLGTG
110
SFGRVMLVKH
120
KATEQYYAMK
130
ILDKQKVVKL
140
KQIEHTLNEK
150
RILQAVEFPF
160
LVRLEYSFKD
170
NSNLYMVMEY
180
VPGGEMFSHL
190
RRIGRFSEPH
200
ARFYAAQIVL
210
TFEYLHSLDL
220
IYRDLKPENL
230
LIDHQGYIQV
240
TDFGFAKRVK
250
GRTWTLCGTP
260
EYLAPEIILS
270
KGYNKAVDWW
280
ALGVLIYEMA
290
AGYPPFFADQ
300
PIQIYEKIVS
310
GKVRFPSHFS
320
SDLKDLLRNL
330
LQVDLTKRFG
340
NLKNGVSDIK
350
THKWFATTDW
360
IAIYQRKVEA
370
PFIPKFRGSG
380
DTSNFDDYEE
390
EEIRVSITEK
CGKEFCEF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0097546 |
ciliary base |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004691 |
cAMP-dependent protein kinase activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Biological Process |
GO:0051447 |
negative regulation of meiotic cell cycle |
| Biological Process |
GO:1904262 |
negative regulation of TORC1 signaling |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.