Search Results
Overview
| Uniprot ID | A0A8I6A4L2 |
|---|---|
| Protein Name | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial |
| Gene Name | Suclg1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | VGGTTPGKGGKKHLG |
| 108 | TPGKGGKKHLGLPVF |
| 119 | LPVFNTVKEAKEKTG |
| 322 | GAIIAGGKGGAKEKI |
| 62 | GSYTASRKNIYIDKN |
| 68 | RKNIYIDKNTKVICQ |
| 71 | IYIDKNTKVICQGFT |
| 80 | ICQGFTGKQGTFHSQ |
Function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase
Protein Sequence
10
MPRSWGGPES
20
VIGGMTAAVV
30
AAAATATMVS
40
GSSGLAAARL
50
LSRTFLLQQN
60
GIRHGSYTAS
70
RKNIYIDKNT
80
KVICQGFTGK
90
QGTFHSQQAL
100
EYGTKLVGGT
110
TPGKGGKKHL
120
GLPVFNTVKE
130
AKEKTGATAS
140
VIYVPPPFAA
150
AAINEAIDAE
160
IPLVVCITEG
170
IPQQDMVRVK
180
HKLTRQGKTR
190
LIGPNCPGII
200
NPGECKIGIM
210
PGHIHKKGRI
220
GIVSRSGTLT
230
YEAVHQTTQV
240
GLGQSLCIGI
250
GGDPFNGTNF
260
IDCLDVFLKD
270
PATEGIVLIG
280
EIGGHAEENA
290
AEFLKEHNSG
300
PKAKPVVSFI
310
AGITAPPGRR
320
MGHAGAIIAG
330
GKGGAKEKIS
340
ALQSAGVIVS
350
MSPAQLGTCM
360
YKVKFKNSAL
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0110052 | toxic metabolite repair |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.