Search Results
Overview
| Uniprot ID | A0A8I6A4U7 |
|---|---|
| Protein Name | F-actin-capping protein subunit alpha-2 |
| Gene Name | Capza2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | PKNRICFKFDHLRKE |
| 371 | QLPVTRTKIDWNKIL |
| 381 | WNKILSYKIGKEMQN |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments
Protein Sequence
10
MTEDTIAIRL
20
WRRCARAQWR
30
SGLRSGEGGG
40
ALGRVRGGLR
50
KAELPGVCAV
60
AWIREAELRG
70
ACAAAWAAGP
80
SLGGGARRGR
90
PHGKGEVRWP
100
LLPPAPRFVA
110
RRKMADLEEQ
120
LSDEEKVRIA
130
AKFIIHAPPG
140
EFNEVFNDVR
150
LLLNNDNLLR
160
EGAAHAFAQY
170
NLDQFTPVKI
180
EGYEDQVLIT
190
EHGDLGNGKF
200
LDPKNRICFK
210
FDHLRKEATD
220
PRPYEAENAI
230
ESWRTSVETA
240
LRAYVKEHYP
250
NGVCTVYGKK
260
VDGQQTIIAC
270
IESHQFQAKN
280
FWNGRWRSEW
290
KFTVTPSTTQ
300
VVGILKIQVH
310
YYEDGNVQLV
320
SHKDIQDSLT
330
VSNEVQTAKE
340
FIKIVEAAEN
350
EYQTAISENY
360
QTMSDTTFKA
370
LRRQLPVTRT
380
KIDWNKILSY
KIGKEMQNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.