Search Results
Overview
| Uniprot ID | A0A8I6A4Z4 |
|---|---|
| Protein Name | Probable proline--tRNA ligase, mitochondrial |
| Gene Name | Pars2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 387 | IPPKKGSKEAAATEI |
Function
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro)
Protein Sequence
10
MYQGIMEGLL
20
TRCRTLSALA
30
TCSLRHSRCI
40
VRKCYHCAPG
50
RGQRLVVSRM
60
FQPQNLREDQ
70
VLSLEGRASD
80
LTCKSQRLML
90
QVGLILPASP
100
GCYHLMPYTV
110
RAVEKLVRVI
120
DQEMQAIGGQ
130
KINMPSLSPA
140
ELWRATGRWD
150
LMGRELLRLK
160
DRHGKEYCLG
170
PTHEEAVTAL
180
VASQKKLSYK
190
QLPLLLYQVT
200
RKFRDEPRPR
210
FGLLRGREFY
220
MKDMYTFDSS
230
SEAAQETYSL
240
VCDAYCRLFD
250
RLGLRWMKAR
260
ADVGSIGGTM
270
SHEFQLPVDI
280
GEDRLVVCPS
290
CHFSANTEIV
300
DLSQKICPDC
310
QGPLTETKGI
320
EVGHTFYLGT
330
KYSSIFNAHF
340
TNAHGESLLA
350
EMGCYGLGVT
360
RILAAAIEVL
370
STEDCIRWPS
380
LLAPYQVCII
390
PPKKGSKEAA
400
ATEIVERLYD
410
DVTEALPQLR
420
GEVLLDDRTH
430
LTIGNRLKDA
440
NKLGYPFVII
450
ASKRALEDPA
460
HFEVWSQNTG
470
EVVFLTKEGV
480
MELLTGVHVV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004827 | proline-tRNA ligase activity |
| Biological Process | GO:0006433 | prolyl-tRNA aminoacylation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.