Search Results

Overview

Uniprot IDA0A8I6A586
Protein NameTrinucleotide repeat-containing gene 18 protein
Gene NameTnrc18
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1932 RKDTGRAKDRKDPRK
1935 TGRAKDRKDPRKKKR

Function

Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12. Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing

Protein Sequence

10 MDGRDFGPQR 20 SVHGPPPPLL 30 SGLAMDSHRV 40 GAATAGRLPS 50 SGLPGPPPPG 60 KYMAGLNLHP 70 HPGFSHLPSG 80 LYPSYLHLNH 90 LEPPSSGSPL 100 LSQLGQPSIF 110 DTQKDGFYLP 120 APGTLHAHTP 130 SSRTPSGHSS 140 GGTAKGSSRE 150 GTGKDRSSRG 160 GDPPPLFGKK 170 DPRAREEVSG 180 PRGVVDLTQE 190 VRAEGRQDRG 200 SSRLAERLSP 210 FLAEAKAKGA 220 LQPSALSLCN 230 GVVDAGLVAE 240 LSRGGAKEVA 250 RQEENARLLR 260 RAEALLPAAR 270 PCGSPLPPPP 280 PPLPPKGPPA 290 PPSSTPAGVY 300 TVFREPGREH 310 RVVAPTFVPS 320 VEAFDERVGP 330 IQIASQARDV 340 RAREREPGRP 350 GVLQGPPGSP 360 RLERPEVLRE 370 KSSVIRSLKR 380 PPPSDGPPAA 390 RSSRSSPDAR 400 AYLPPKELLK 410 PEADPRPCER 420 APRGPSSSAA 430 QQAAKLFGLE 440 PSRPPGPEHK 450 WKPFELGNFA 460 TTQMAVLAAQ 470 HHHASRAEEE 480 AAVATASKKA 490 YLDPGGAMPR 500 ASATCGRPGA 510 DLHSAAAHGP 520 GEASAMQSLI 530 KYSGSFAREA 540 VAVRPGGCGK 550 KSPFGGLGTM 560 KPEPIPTSAG 570 PPRAQARLTH 580 PGVPTAGGGR 590 QLKRDPERPE 600 SAKTFGREGS 610 GAQGEAEVRH 620 PPVGIAVAVA 630 RQKDSGSSSR 640 LGPGLIDQER 650 SLSLNNVKGH 660 GRTEDDCDRA 670 RHREDRLLGT 680 RLDRDQEKLL 690 RESKELADLA 700 RLHPTSCAPN 710 GLNPNLMVTG 720 GPTLAGSGRW 730 SADPAAHLAT 740 HPWLPRSGST 750 SMWLAGHPYG 760 LGPPSLHQGM 770 APAFPPGLGG 780 SLPSAYQFVR 790 DPQSGQLVVI 800 PSDHLPHFAE 810 LMERATVPPL 820 WPALYPPGRS 830 PLHHAQQLQL 840 FSQQHFLRQQ 850 ELLYLQQQAA 860 QALELQRSAQ 870 LVQERLKAQE 880 HRTEMEEKIT 890 KRGLETTGKA 900 GLSATGPGLL 910 PQKSAGLATG 920 PTGTHGKAMS 930 PPPSPRASPV 940 TSLKAKVIQK 950 VEDVSKPPAY 960 TYPATPSSHP 970 SSPPPASPPP 980 TPGLTRKEEA 990 PENVVEKKDL 1000 ELEKEAPSPF 1010 QALFTDIPPR 1020 YPFQALPPHY 1030 GRPYPFLLQP 1040 TAAADADGLA 1050 PDVPLPADGP 1060 ERLALSPEDK 1070 PICLSPSKIP 1080 EPPRDSQEEE 1090 RLADREVKAE 1100 IEDIEEGPTE 1110 LPRLESPLAL 1120 PVPETMVAVS 1130 PAGGCGGSPL 1140 EAQALSTAGP 1150 GCREPSEVSD 1160 FAQVAEPQIE 1170 LPSRTEPHMA 1180 ALELGTQLTP 1190 EPLVEAKEEP 1200 VEVPLDVPME 1210 EPVAETGPED 1220 SLPQPPLTEP 1230 PPSLELSDCD 1240 LPVPEGQCLN 1250 LEAQEAAPAP 1260 ASTYLEETHP 1270 ESLLPGLDDP 1280 LAGMNALAAA 1290 AELPQARPLP 1300 SLGTGVPGGE 1310 KLDTAPSLVL 1320 EHSFLQGITL 1330 LSEIAELELD 1340 RRGQEVPGPE 1350 PNLVVRPSLE 1360 SLLAASSHML 1370 KEVLESPLSD 1380 SLKNLRLPRE 1390 LNSNKKYSWM 1400 QKKEERMFAM 1410 KSSLEDMDAL 1420 ELDFRMRLAE 1430 VQRRYKEKQR 1440 ELVKLQRRRD 1450 SGLSSKSLLT 1460 SDDYDLGAGI 1470 RKRHKGPEEE 1480 QEALVSMGKA 1490 RSRNQSWDDH 1500 ESSSDFMSQL 1510 KIKKKKMSSD 1520 QEQLASKLDR 1530 ALSLTKQDKL 1540 KSPFKFSDSP 1550 GGKWKTSGGC 1560 GRFLTQCDSL 1570 LGKDRKALAK 1580 GLGLSLKPSR 1590 EGKHKRASKA 1600 RKMEGGFKAR 1610 GQPKSVHSPF 1620 ASEVSSHSYN 1630 TDSDEDEDLL 1640 KNSWSAQGPS 1650 SSKLTSSLLG 1660 MVAKNSKPAT 1670 GPKLTKRGPS 1680 GPRTLKPKEA 1690 TSRKQSFCLL 1700 LREAEAHSSF 1710 SDSSAEDSFD 1720 QDDSSEEEEE 1730 ELEEEEEDEE 1740 EEGIGSYRLG 1750 AGEQALSPSL 1760 EESGLGLLAR 1770 FAASALPSPV 1780 VGPPLSVVQL 1790 EAEQKARKKE 1800 ERQSLMGTEF 1810 EYTDSESEVK 1820 VPKQSPAGLL 1830 RPKKGAGEPG 1840 QSLAAPVPGT 1850 RASGPTSPDK 1860 AKLASEKGRK 1870 ARKIRGSKEP 1880 GFEAGPEASD 1890 DDLWTRRRSE 1900 RIFLHDASAA 1910 VQAPSNAAPA 1920 TKPSRCGRGG 1930 APSPRKDTGR 1940 AKDRKDPRKK 1950 KRGKEAGSAA 1960 TLPSPRVSTL 1970 PDSRAPHPGA 1980 LATAKRSKAK 1990 ARGKEAKKEN 2000 RGKGGAVSKL 2010 MECMAAEEDF 2020 EPNQDSSFSE 2030 DEHLPRGGAT 2040 ERPLTPAPRS 2050 CIIDKEELKD 2060 GLRVLIPMDD 2070 KLLYAGHVQT 2080 VHSPDIYRVV 2090 VEGERGNRPH 2100 IYCLEQLLQE 2110 AIIDVRPAST 2120 RFLPQGTRIA 2130 AYWSQQYRCL 2140 YPGTVVRGLL 2150 DLEDDGDLIT 2160 VEFDDGDTGR 2170 IPLSHIRLLP 2180 PDYKIQCAEP 2190 SPALLVPSAK 2200 RRSRKTSKDT 2210 GEGKEGAATG 2220 PQEATGGKAR 2230 GRGRKPSTKA 2240 KADRAVVLEE 2250 GAATNELPSA 2260 PLALEPVSTP 2270 NSKKSTPEPV 2280 DKRARAPKAR 2290 SVSVQPSPGP 2300 PTFSSCPAPE 2310 PFGELPTPAT 2320 APLVTMPVTM 2330 PATRPKPKKA 2340 RATEGSGAKG 2350 PRRPGEDDEL 2360 LVKLDHEGVM 2370 SPKSKKAKEA 2380 LLLREDPGPG 2390 AWPESTGLLS 2400 LGSYSPTVGS 2410 SEPKATWPKG 2420 LDGDLTQEPG 2430 PGLPLEDPGN 2440 SKSPDKAQAE 2450 QDGAEESETT 2460 SSSSSSSSSS 2470 SSSSSSSSSS 2480 SSSSSGSETE 2490 GEEDAEKNRE 2500 DGRGAGGRTC 2510 SAASSRASSP 2520 ASSSSSSSSS 2530 SSSSSSSSSS 2540 SSSSSSSSSS 2550 SSSSSSSSSS 2560 SSSSSSTTDE 2570 DSSCSSDDEA 2580 APAPAAGPST 2590 QPALPTKVSK 2600 PPSKARASAH 2610 SPGKKAPPTT 2620 QPPPQPPPQP 2630 QQTLQPKTQT 2640 GAGAKSRPKK 2650 REGVHLPTTK 2660 ELAKRQRLPS 2670 VENRPKIAAF 2680 LPARQLWKWF 2690 GKPTQRRGMK 2700 GKARKLFYKA 2710 IVRGKEMIRI 2720 GDCAVFLSAG 2730 RPNLPYIGRI 2740 QSMWESWGNN 2750 MVVRVKWFYH 2760 PEETSPGKQF 2770 HEGQHWDQKS 2780 GHNLPAALRA 2790 SSQRKDFMER 2800 ALYQSSHVDE 2810 NDVQTVSHKC 2820 LVVGLEQYEQ 2830 MLKTKKYQDS 2840 EGLYYLAGTY 2850 EPTTGMIFST DGVPVLC

Gene Ontology

Classification GO ID Description
Molecular Function GO:0003682 chromatin binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.