Search Results
Overview
| Uniprot ID | A0A8I6A5C2 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | Dctn2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | VKETPQQKYQRLLHE |
| 129 | EKIKTTVKESATEEK |
| 136 | KESATEEKLTPVVLA |
| 150 | AKQLAALKQQLVASH |
| 228 | DKFSQAAKVAELEKR |
| 302 | VNEIAKHKASVEDAD |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
Protein Sequence
10
MYPLFVLPSL
20
HSQGWEARNE
30
PDVYETSDLP
40
EDDQAEFDAE
50
ELSSTSVEHI
60
IVNPNAAYDK
70
FKDKRVGTKG
80
LDFSDRIGKT
90
KRTGYESGDY
100
EMLGEGLGVK
110
ETPQQKYQRL
120
LHEVQELTTE
130
VEKIKTTVKE
140
SATEEKLTPV
150
VLAKQLAALK
160
QQLVASHLEK
170
LLGPDAAINL
180
ADPDGALAKR
190
LLLQLEATKS
200
SKGSSGGKST
210
GGTPPDSSLV
220
TYELHSRPEQ
230
DKFSQAAKVA
240
ELEKRLTELE
250
ATVRCDQDAQ
260
NPLSAGLQGA
270
CLMETVELLQ
280
AKVNALDLAV
290
LDQVEARLQS
300
VLGKVNEIAK
310
HKASVEDADT
320
QNKVHQLYET
330
IQRWSPVAST
340
LPELVQRLVT
350
IKQLHEQAMQ
360
FGQLLTHLDT
370
TQQMMASSLK
380
DNTALLTQVQ
390
TTMRENLATV
400
EGNFASIDAR
MKKLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.