Search Results
Overview
| Uniprot ID | A0A8I6A5L3 |
|---|---|
| Protein Name | T-complex protein 1 subunit beta |
| Gene Name | Cct2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | SKLLTHHKDHFTKLA |
| 189 | VEAVLRLKGSGNLEA |
| 201 | LEAIHVIKKLGGSLA |
| 246 | NTGMDTDKIKIFGSR |
| 261 | VRVDSTAKVAEIEHA |
| 270 | AEIEHAEKEKMKEKV |
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia
Protein Sequence
10
MCLIEYWRSN
20
GAGADEERAE
30
TARLSSFIGA
40
IAIGDLVKST
50
LGPKGMDKIL
60
LSSGRDASLM
70
VTNDGATILK
80
NIGVDNPAAK
90
VLVDMSRVQD
100
DEVGDGTTSV
110
TVLAAELLRE
120
AESLIAKKIH
130
PQTIIAGWRE
140
ATKAAREALL
150
SSAVDHGSDE
160
VKFWQDLMNI
170
AGTTLSSKLL
180
THHKDHFTKL
190
AVEAVLRLKG
200
SGNLEAIHVI
210
KKLGGSLADS
220
YLDEGFLLDK
230
KIGVNQPKRI
240
ENAKILIANT
250
GMDTDKIKIF
260
GSRVRVDSTA
270
KVAEIEHAEK
280
EKMKEKVERI
290
LKHGINCFIN
300
RQLIYNYPEQ
310
LFGAAGVMAI
320
EHADFAGVER
330
LALVTGGEIA
340
STFDHPELVK
350
LGSCKLIEEV
360
MIGEDKLIHF
370
SGVALGEACT
380
IVLRGATQQI
390
LDEAERSLHD
400
ALCVLAQTVK
410
DPRTVYGGGC
420
SEMLMAHAVT
430
MLASRTPGKE
440
AVAMESFAKA
450
LRMLPTIIAD
460
NAGYDSADLV
470
AQLRAAHSEG
480
RITAGLDMKE
490
GSIGDMAVLG
500
ITESFQVKRQ
510
VLLSAAEAAE
520
VILRVDNIIK
AAPRY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005832 | chaperonin-containing T-complex |
| Cellular Component | GO:0002199 | zona pellucida receptor complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0140662 | ATP-dependent protein folding chaperone |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0007339 | binding of sperm to zona pellucida |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.