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Overview

Uniprot ID	A0A8I6A6K6
Protein Name	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
Gene Name	Ppp2r5d
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
142	PTQLSKIKYSGGPQI
151	SGGPQIVKKERRQSS
641	DKVLLRRKSELPQDV

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Protein Sequence

10 MRKKGSCLAP 20 MTNPRRRRLV 30 VRQVCKSSGQ 40 LEAQPPLGPG 50 AARRRWRRDA 60 ERAECGRAEP 70 EPERGRRSRA 80 GCGPAEMPYK 90 LKKDKEPPKL 100 AKGTAKPSSS 110 SKDGGGENTD 120 TEAQPQPQPQ 130 PPSSNKRPSN 140 STPPPTQLSK 150 IKYSGGPQIV 160 KKERRQSSSR 170 FNLSKNRELQ 180 KLPALKDSPT 190 QEREELFIQK 200 LRQCCVLFDF 210 VSDPLSDLKF 220 KEVKRAGLNE 230 MVEYITHSRD 240 VVTEAIYPEA 250 VTMFSVNLFR 260 TLPPSSNPTG 270 AEFDPEEDEP 280 TLEAAWPHLQ 290 LVYEFFLRFL 300 ESPDFQPNIA 310 KKYIDQKFVL 320 ALLDLFDSED 330 PRERDFLKTI 340 LHRIYGKFLG 350 LRAYIRRQIN 360 HIFYRFIYET 370 EHHNGIAELL 380 EILGSIINGF 390 ALPLKEEHKM 400 FLIRVLLPLH 410 KVKSLSVYHP 420 QLAYCVVQFL 430 EKESSLTEPV 440 IVGLLKFWPK 450 THSPKEVMFL 460 NELEEILDVI 470 EPSEFSKVME 480 PLFRQLAKCV 490 SSPHFQVAER 500 ALYYWNNEYI 510 MSLISDNAAR 520 VLPIMFPALY 530 RNSKSHWNKT 540 IHGLIYNALK 550 LFMEMNQKLF 560 DDCTQQYKAE 570 KQKGRFRMKE 580 REEMWQKIEE 590 LARLNPQYPM 600 FRAPPPLPPV 610 YSMETETPTA 620 EDIQLLKRTV 630 ETEAVQMLKD 640 IKKDKVLLRR 650 KSELPQDVYT 660 IKALEAHKRA 670 EEFLTASQEA L

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000159	protein phosphatase type 2A complex
Molecular Function	GO:0072542	protein phosphatase activator activity
Biological Process	GO:0051177	meiotic sister chromatid cohesion
Biological Process	GO:0007165	signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.