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Overview

Uniprot ID	A0A8I6A6X9
Protein Name	Neutral alpha-glucosidase AB
Gene Name	Ganab
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
701	AAVVLQTKGSPESRL

Function

Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia

Protein Sequence

10 MPVDLWLLSI 20 RGLPGSRKNQ 30 KMQLKATEPS 40 LKQGLGMPEE 50 TQEKAEKDEP 60 GAWEETFKTH 70 SDSKPYGPTS 80 VGLDFSLPGM 90 EHVYGIPEHA 100 DSLRLKVTEG 110 GEPYRLYNLD 120 VFQYELNNPM 130 ALYGSVPVLL 140 AHSFHRDLGI 150 FWLNAAETWV 160 DISSNTAGKT 170 LFGKMLDYLQ 180 GSGETPQTDI 190 RWMSESGIVD 200 VFLMLGPSVL 210 DVFRQHASLT 220 GTQALPPLFS 230 LGYHQSRWNY 240 RDEADVLEVD 250 QGFDDHNMPC 260 DVIWLDIEHA 270 DGKRYFTWDP 280 TRFPQPLNML 290 EHLASKRRKL 300 VAIVDPHIKV 310 DSGYRVHEEL 320 RNHGLYVKTR 330 DGSDYEGWCW 340 PGSASYPDFT 350 NPQMRAWWAN 360 MFNFHNYEGS 370 APNLFVWNDM 380 NEPSVFNGPE 390 VTMLKDAVHY 400 GGWEHRDIHN 410 IYGLYVHMAT 420 ADGLIQRSGG 430 IERPFVLSRA 440 FFSGSQRFAD 450 VGGFFKNPEP 460 ELLVRWYQMG 470 AYQPFFRAHA 480 HLDTGRREPW 490 LLASQYQDAI 500 RDALFQRYSL 510 LPFWYTLFYQ 520 AHQEGFPVMR 530 PLWVQYPEDM 540 STFSMEDQFM 550 LGDALLIHPV 560 SDAGAHGVQV 570 YLPGEEEVWY 580 DIQSYQKHHG 590 PQTLYLPVTL 600 SSIPVFQRGG 610 TIVPRWMRVR 620 RSSDCMKEDP 630 ITLFVALSAQ 640 GTAQGELFLD 650 DGHTFNYQNR 660 HEFLLRRFSF 670 SGNTLVSSSA 680 DPKGHLETPV 690 WIERVVIMGA 700 GKPAAVVLQT 710 KGSPESRLSF 720 QHDPETSVLT 730 LRKPGVNVAS DWSIHLR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0017177	glucosidase II complex
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0042470	melanosome
Molecular Function	GO:0030246	carbohydrate binding
Molecular Function	GO:0106407	Glc2Man9GlcNAc2 oligosaccharide glucosidase activity
Molecular Function	GO:0033919	glucan 1,3-alpha-glucosidase activity
Biological Process	GO:0005975	carbohydrate metabolic process
Biological Process	GO:0006491	N-glycan processing

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.