Search Results
Overview
| Uniprot ID | A0A8I6A721 |
|---|---|
| Protein Name | Malate dehydrogenase |
| Gene Name | Mdh1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | MERKDLLKANVKIFK |
| 115 | KANVKIFKSQGAALE |
| 123 | SQGAALEKYAKKSVK |
| 147 | TNCLTASKSAPSIPK |
| 154 | KSAPSIPKENFSCLT |
| 169 | RLDHNRAKSQIALKL |
| 175 | AKSQIALKLGVTADD |
| 204 | YPDVNHAKVKLQGKE |
| 210 | AKVKLQGKEVGVYEA |
| 241 | QRGAAVIKARKLSSA |
| 244 | AAVIKARKLSSAMSA |
| 303 | VIKNKTWKFVEGLPI |
| 317 | INDFSREKMDLTAKE |
| 323 | EKMDLTAKELTEEKE |
Function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)
Protein Sequence
10
MHRLIKSEPI
20
RVLVTGAAGQ
30
IAYSLLYSIG
40
NGSVFGKDQP
50
IILVLLDITP
60
MMGVLDGVLM
70
ELQDCALPLL
80
QDVIATDKEE
90
VAFKDLDVAV
100
LVGSMPRREG
110
MERKDLLKAN
120
VKIFKSQGAA
130
LEKYAKKSVK
140
VIVVGNPANT
150
NCLTASKSAP
160
SIPKENFSCL
170
TRLDHNRAKS
180
QIALKLGVTA
190
DDVKNVIIWG
200
NHSSTQYPDV
210
NHAKVKLQGK
220
EVGVYEALKD
230
DSWLKGEFIT
240
TVQQRGAAVI
250
KARKLSSAMS
260
AAKAISDHIR
270
DIWFGTPEGE
280
FVSMGVISDG
290
NSYGVPDDLL
300
YSFPVVIKNK
310
TWKFVEGLPI
320
NDFSREKMDL
330
TAKELTEEKE
TAFEFLSSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0030060 | L-malate dehydrogenase (NAD+) activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0043490 | malate-aspartate shuttle |
| Biological Process | GO:0006739 | NADP+ metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.