Search Results

Overview

Uniprot IDA0A8I6A732
Protein NameUnconventional myosin-Va
Gene NameMyo5a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1017 EERADKYKQETEQLV
1232 LRKALSEKSAPEVTA
389 TATETYIKPISKLQA
55 LEYRLDPKTSELPHL
621 RVPVKPTKGRPGQTA

Function

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation

Protein Sequence

10 MAASELYTKF 20 ARVWIPDPEE 30 VWKSAELLKD 40 YKPGDKVLLL 50 HLEEGKDLEY 60 RLDPKTSELP 70 HLRNPDILVG 80 ENDLTALSYL 90 HEPAVLHNLR 100 VRFIDSKLIY 110 TYCGIVLVAI 120 NPYEQLPIYG 130 EDIINAYSGQ 140 NMGDMDPHIF 150 AVAEEAYKQM 160 ARDERNQSII 170 VSGESGAGKT 180 VSAKYAMRYF 190 ATVSGSASEA 200 NVEEKVLASN 210 PIMESIGNAK 220 TTRNDNSSRF 230 GKYIEIGFDK 240 RYRIIGANMR 250 TYLLEKSRVV 260 FQAEEERNYH 270 IFYQLCASAK 280 LPEFKMLRLG 290 NADSFHYTKQ 300 GGSPMIEGVD 310 DAKEMAHTRQ 320 ACTLLGISES 330 YQMGIFRILA 340 GILHLGNVGF 350 ASRDSDSCTI 360 PPKHEPLIIF 370 CDLMGVDYEE 380 MCHWLCHRKL 390 ATATETYIKP 400 ISKLQATNAR 410 DALAKHIYAK 420 LFNWIVGHVN 430 QALHSAVKQH 440 SFIGVLDIYG 450 FETFEINSFE 460 QFCINYANEK 470 LQQQFNMHVF 480 KLEQEEYMKE 490 QIPWTLIDFY 500 DNQPCINLIE 510 SKLGILDLLD 520 EECKMPKGTD 530 DTWAQKLYNT 540 HLNKCALFEK 550 PRMSNKAFII 560 KHFADKVEYQ 570 CEGFLEKNKD 580 TVFEEQIKVL 590 KSSKFKMLPE 600 LFQDDEKAIS 610 PTSATSSGRT 620 PLTRVPVKPT 630 KGRPGQTAKE 640 HKKTVGLQFR 650 NSLHLLMETL 660 NATTPHYVRC 670 IKPNDFKFPF 680 TFDEKRAVQQ 690 LRACGVLETI 700 RISAAGFPSR 710 WTYQEFFSRY 720 RVLMKQKDVL 730 GDRKQTCQNV 740 LEKLILDKDK 750 YQFGKTKIFF 760 RAGQVAYLEK 770 LRADKLRAAC 780 IRIQKTIRGW 790 LLRKRYLCMQ 800 RAAITVQRYV 810 RGYQARCYAK 820 FLRRTKAATT 830 IQKYWRMYVV 840 RRKYKIRRAA 850 TIVLQSYLRG 860 YLARNRYRKI 870 LREHKAVIIQ 880 KRVRGWLART 890 HYKRTMKAII 900 YLQCCFRRMM 910 AKRELKKLKI 920 EARSVERYKK 930 LHIGMENKIM 940 QLQRKVDEQN 950 KDYKCLMEKL 960 TNLEGVYNSE 970 TEKLRNDVER 980 LQLSEEEAKV 990 ATGRVLSLQE 1000 EIAKLRKDLE 1010 QTRSEKKSIE 1020 ERADKYKQET 1030 EQLVSNLKEE 1040 NTLLKQEKET 1050 LNHLMVEQAK 1060 EMTETMERKL 1070 VEETKQLELD 1080 LNDERLRYQN 1090 LLNEFSRLEE 1100 RYDDLKEEMT 1110 LMLNVPKPGH 1120 KRTDSTHSSN 1130 ESEYTFSSEF 1140 AETEDIAPRT 1150 EEPTEKKVPL 1160 DMSLFLKLQK 1170 RVTELEQEKQ 1180 LMQDELDRKE 1190 EQVLRSKAKE 1200 EERPQIRGAE 1210 LEYESLKRQE 1220 LESENKKLKN 1230 ELNELRKALS 1240 EKSAPEVTAP 1250 GAPAYRVLME 1260 QLTAVSEELD 1270 VRKEEVLILR 1280 SQLVSQKEAI 1290 QPKDDKNTMT 1300 DSTILLEDVQ 1310 KMKDKGEIAQ 1320 AYIGLKETNR 1330 LLESQLQSQK 1340 RSHENEAEAL 1350 RGEIQSLKEE 1360 NNRQQQLLAQ 1370 NLQLPPEARI 1380 EASLQHEITR 1390 LTNENLYFEE 1400 LYADDPKKYQ 1410 SYRISLYKRM 1420 IDLMEQLEKQ 1430 DKTVRKLKKQ 1440 LKVFAKKIGE 1450 LEVGQMENIS 1460 PGQIIDEPIR 1470 PVNIPRKEKD 1480 FQGMLEYKRE 1490 DEQKLVKNLI 1500 LELKPRGVAV 1510 NLIPGLPAYI 1520 LFMCVRHADY 1530 LNDDQKVRSL 1540 LTSTINSIKK 1550 VLKKRGDDFE 1560 TVSFWLSNTC 1570 RFLHCLKQYS 1580 GEEGFMKHNT 1590 SRQNEHCLTN 1600 FDLAEYRQVL 1610 SDLAIQIYQQ 1620 LVRVLENILQ 1630 PMIVSGMLEH 1640 ETIQGVSGVK 1650 PTGLRKRTSS 1660 IADEGTYTLD 1670 SILRQLNSFH 1680 SVMCQHGMDP 1690 ELIKQVVKQM 1700 FYIVGAITLN 1710 NLLLRKDMCS 1720 WSKGMQIRYN 1730 VSQLEEWLRD 1740 KNLMNSGAKE 1750 TLEPLIQAAQ 1760 LLQVKKKTDD 1770 DAEAICSMCN 1780 ALTTAQIVKV 1790 LNLYTPVNEF 1800 EERVSVSFIR 1810 TIQVRLRDRK 1820 DSPQLLMDAK 1830 HIFPVTFPFN 1840 PSSLALETIQ 1850 IPASLGLGFI ARV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016459 myosin complex
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0003774 cytoskeletal motor activity
Biological Process GO:0015031 protein transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.