Overview
| Uniprot ID | A0A8I6A7P5 |
|---|
| Protein Name | Tricarboxylate transport protein, mitochondrial |
|---|
| Gene Name | Slc25a1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 237 |
DCGVQILKNEGPKAF |
Function
Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes
Protein Sequence
10
MNARTHRGTG
20
ALGTACGKLS
30
AAMASWACTA
40
ASAPCSTAPS
50
PRRLSGETRL
60
CRNDQEGVAR
70
AAPSHDFFFR
80
FGMFEFLSNH
90
MRDAQGRLDS
100
RRGLLCGLGA
110
GVAEAVVVVC
120
PMETVKVKFI
130
HDQTSSNPKY
140
RGFFHGVREI
150
VREQGLKGTY
160
QGLTATVLKQ
170
GSNQAIRFFV
180
MTSLRNWYQG
190
DNPNKPMNPL
200
ITGVFGAVAG
210
AASVFGNTPL
220
DVIKTRMQGL
230
EAHKYRNTLD
240
CGVQILKNEG
250
PKAFYKGTVP
260
RLGRVCLDVA
270
IVFVIYDEVV
280
KLLNKVWKTD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.