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Overview

Uniprot IDA0A8I6A8A4
Protein NameElongation factor 2
Gene NameEef2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
211 YVAKFAAKGEGQLGA
411 PNYTPGKKEDLYLKP
484 VRVAVEAKNPADLPK
544 HACIPIKKSDPVVSY

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome

Protein Sequence

10 MSVNFTVDQI 20 RAIMDKKANI 30 RNMSVIAHVD 40 HGKSTLTDSL 50 VCKAGIIASA 60 RAGETRFTDT 70 RKDEQERCIT 80 IKSTKDGSGF 90 LINLIDSPGH 100 VDFSSEVTAA 110 LRVTDGALVV 120 VDCVSGVCVQ 130 TETVLRQAIA 140 ERIKPVLMMN 150 KMDRALLELQ 160 LEPEELYQTF 170 QRIVENVNSG 180 PMGNIMIDPV 190 LGTVGFGSGL 200 HGWAFTLKQF 210 AEMYVAKFAA 220 KGEGQLGAAE 230 RAKKVEDMMK 240 KLWGDRYFDP 250 ANGKFSKSAN 260 SPDGKKLPRT 270 FCQLILDPIF 280 KVFDAIMNFR 290 KEETAKLIEK 300 LDIKLDSEDK 310 DKEGKPLLKA 320 VMRRWLPAGD 330 ALLQMITIHL 340 PSPVTAQKYR 350 CELLYEGPPD 360 DEAAMGIKSC 370 DPKGPLMMYI 380 SKMVPTSDKG 390 RFYAFGRVFS 400 GVVSTGLKVR 410 IMGPNYTPGK 420 KEDLYLKPIQ 430 RTILMMGRYV 440 EPIEDVPCGN 450 IVGLVGVDQF 460 LVKTGTITTF 470 EHAHNMRVMK 480 FSVSPVVRVA 490 VEAKNPADLP 500 KLVEGLKRLA 510 KSDPMVQCII 520 EESGEHIIAG 530 AGELHLEICL 540 KDLEEDHACI 550 PIKKSDPVVS 560 YRETVSEESN 570 VLCLSKSPNK 580 HNRLYMKARP 590 FPDGLAEDID 600 KGEVSARQEL 610 KARARYLAEK 620 YEWDVAEARK 630 IWCFGPDGTG 640 PNILTDITKG 650 VQYLNEIKDS 660 VVAGFQWATK 670 EGALCEENMR 680 GVRFDVHDVT 690 LHADAIHRGG 700 GQIIPTARRC 710 LYASVLTAQP 720 RLMEPIYLVE 730 IQCPEQVVGG 740 IYGVLNRKRG 750 HVFEESQVAG 760 TPMFVVKAYL 770 PVNESFGFTA 780 DLRSNTGGQA 790 FPQCVFDHWQ 800 ILPGDPFDNS 810 SRPSQVVAET 820 RKRKGLKEGI 830 PALDNFLDKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005840 ribosome
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003746 translation elongation factor activity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.