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Overview

Uniprot ID	A0A8I6A960
Protein Name	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Gene Name	Paics
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
381	TAGNAARKNHLEGKA

Function

Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway

Protein Sequence

10 MESGPGKHWT 20 EEEVKALLSV 30 WAERNIRKQL 40 YGTLRNREIF 50 IYVAKRLRSL 60 GVYRDWKQCR 70 AKYKNLKYEY 80 RTVKHAHRSG 90 DSSRTMKFFH 100 VLDAILQSEP 110 TARLTEESDG 120 NIKCLVTLSS 130 SSAPEITEGN 140 RIPLEGAESH 150 THTVTSNDPG 160 AGRHQPENEV 170 TALVQIWHGE 180 RVRQTPEETT 190 RNKGTSEETA 200 QRPIQFGIDR 210 DWKQCHDATH 220 KTPNREQRVL 230 QKTNDSPWRK 240 RRFHDETDCI 250 LKSRTPGITK 260 RKHESPEGHF 270 GSLGTGSNKR 280 KAQEGETMST 290 PLKKMSPEII 300 TNWFPQSLID 310 LEGSTGCFFH 320 QDPHLHQIAA 330 SFSRAVCSSS 340 SPRIMATAEV 350 LNIGRKLYEG 360 KTKEVYELLD 370 SPGRVLLQSK 380 DQITAGNAAR 390 KNHLEGKAAI 400 SNKITSCIFQ 410 LLQEAGIKTA 420 FTKKCGETAF 430 IAPQCEMIPI 440 EWVCRRIATG 450 SFLKRNPGVK 460 EGYRFYPPKV 470 EMFFKDDANN 480 DPQWSEEQLI 490 AAKFCFAGLV 500 IGQTEVDIMS 510 HATQAIFEIL 520 EKSWLPQNCT 530 LVDMKIEFGV 540 DVTTKEIVLA 550 DVIDNDSWRL 560 WPSGDRSQQK 570 DKQSYRDLKE 580 VTPEGLQMVK 590 KNFEWVADRV 600 ELLLKSNSQC 610 RVVVLMGSTS 620 DLGHCEKIKK 630 ACGNFGIPCE 640 LRVTSAHKGP 650 DETLRIKAEY 660 EGDGIPTVFV 670 AVAGRSNGLG 680 PVMSGNTAYP 690 VISCPPITAD 700 WGAQDVWSSL 710 RLPSGIGCST 720 ILSPEGSAQF 730 AAQIFGLNNH 740 LVWAKLRASK 750 LNTWISLKQA DKKIRECNL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004638	phosphoribosylaminoimidazole carboxylase activity
Molecular Function	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Biological Process	GO:0006189	'de novo' IMP biosynthetic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.