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Overview

Uniprot IDA0A8I6A993
Protein NameHepatocyte growth factor-regulated tyrosine kinase substrate
Gene NameHgs
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
530 LEIMRQKKQEYLEVQ

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation

Protein Sequence

10 MSRTELVNGG 20 VTLLGSSSVS 30 FQNKATSQLL 40 LETDWESILQ 50 ICDLIRQGDT 60 QAKYAVNSIK 70 KKVNDKNPHV 80 ALYALEVMES 90 VVKNCGQTVH 100 DEVANKQTME 110 ELKELLKRQV 120 EVNVRNKILY 130 LIQAWAHAFR 140 NEPKYKVVQD 150 TYQIMKVEGH 160 VFPEFKESDA 170 MFAAERAPDW 180 VDAEECHRCR 190 VQFGVVTRKH 200 HCRACGQIFC 210 GKCSSKYSTI 220 PKFGIEKEVR 230 VCEPCYEQLN 240 KKAEGKAAST 250 TELPPEYLTS 260 PLSQQSQLPP 270 KRDETALQEE 280 EELQLALALS 290 QSEAEEKERM 300 RQKSTYTAHP 310 KSEPAPLASS 320 APPAGSLYSS 330 PVNSSAPLAE 340 DIDPELARYL 350 NRNYWEKKQE 360 EARKSPTPSA 370 PVPLTEPAAQ 380 PGEGHTAPNS 390 MVEAPLPETD 400 SQPITSCSGP 410 FSEQYQNGES 420 EESHEQFLKA 430 LQNAVSTFVN 440 RMKSNHMRGR 450 SITNDSAVLS 460 LFQSINSTHP 470 QLLELLNRLD 480 ERRLYYEGLQ 490 DKLAQIRDAR 500 GALSALREEH 510 REKLRRAAEE 520 AERQRQIQLA 530 QKLEIMRQKK 540 QEYLEVQRQL 550 AIQRLQEQEK 560 ERQMRLEQQK 570 QTVQMRAQMP 580 AFPLPYAQLQ 590 AMPTAGGVLY 600 QPSGPTSFPG 610 TFSPAGSVEG 620 SPMHGVYMSQ 630 PAPATGPYPS 640 MPGTTADPSM 650 VSAYMYPAGA 660 PGAQAAPQAQ 670 AGPTTNPAYS 680 SYQPTPTPGY 690 QNVASQAPQS 700 LPAISQPPQT 710 SNIGYMGSQP 720 MSMGYQPYNM 730 QNLMTTLPGQ 740 DASLPAQQPY 750 ITGQQPMYQQ 760 MAPSTGPPQQ 770 QPPVAQPPPT 780 QGPPAQGNET QLISFD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0032585 multivesicular body membrane
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0015031 protein transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.