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Overview

Uniprot IDA0A8I6A9X8
Protein NameSuccinyl-CoA:3-ketoacid-coenzyme A transferase
Gene NameOxct1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
156 GSPIKYNKDGSVAIA
276 EGKAKSGKPGEDVRE
401 MIPGKMVKGMGGAMD
414 MDLVSSSKTKVVVTM
416 LVSSSKTKVVVTMEH
426 VTMEHSAKGNAHKIM
435 NAHKIMEKCTLPLTG
443 CTLPLTGKQCVNRII
453 VNRIITEKGVFDVDK

Function

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate

Protein Sequence

10 MFSIFQGCAC 20 YFSVSTRHHT 30 KFYTDPVEAV 40 KDIPNGATLL 50 VGGFGLCGIP 60 ENLIGALLKT 70 GVKDLTAVSN 80 NAGVDNFGLG 90 LLLRSKQIKR 100 MISSYVGENA 110 EFERQFLSGE 120 LEVELTPQGT 130 LAERIRAGGA 140 GVPAFYTSTG 150 YGTLVQEGGS 160 PIKYNKDGSV 170 AIASKPREVR 180 EFRGQHFILE 190 EAITGDFALV 200 KAWKADRAGN 210 VIFRKSARNF 220 NLPMCKAAGT 230 TVVEVEEIVD 240 IGSFAPEDIH 250 IPKIYVHRLI 260 KGEKYEKRIE 270 RLSLRKEGEG 280 KAKSGKPGED 290 VRERIIKRAA 300 LEFEDGMYAN 310 LGIGIPLLAS 320 NFISPNMTVH 330 LQSENGVLGL 340 GPYPLKDEAD 350 ADLINAGKET 360 VTVLPGASFF 370 SSDESFAMIR 380 GGHVNLTMLG 390 AMQVSKYGDL 400 ANWMIPGKMV 410 KGMGGAMDLV 420 SSSKTKVVVT 430 MEHSAKGNAH 440 KIMEKCTLPL 450 TGKQCVNRII 460 TEKGVFDVDK 470 KNGLTLIELW 480 EGLTVDDIRK 490 STGCDFAVSP 500 NLMPMQQIST

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity
Biological Process GO:0046952 ketone body catabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.