Search Results
Overview
| Uniprot ID | A0A8I6AAD9 |
|---|---|
| Protein Name | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial |
| Gene Name | Suclg1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 289 | GAIIAGGKGGAKEKI |
| 29 | GSYTASRKNIYIDKN |
| 35 | RKNIYIDKNTKVICQ |
| 38 | IYIDKNTKVICQGFT |
| 47 | ICQGFTGKQGTFHSQ |
| 71 | VGGTTPGKGGKKHLG |
| 75 | TPGKGGKKHLGLPVF |
| 86 | LPVFNTVKEAKEKTG |
Function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase
Protein Sequence
10
SPGSGCLALL
20
YFWVQQNGIR
30
HGSYTASRKN
40
IYIDKNTKVI
50
CQGFTGKQGT
60
FHSQQALEYG
70
TKLVGGTTPG
80
KGGKKHLGLP
90
VFNTVKEAKE
100
KTGATASVIY
110
VPPPFAAAAI
120
NEAIDAEIPL
130
VVCITEGIPQ
140
QDMVRVKHKL
150
TRQGKTRLIG
160
PNCPGIINPG
170
ECKIGIMPGH
180
IHKKGRIGIV
190
SRSGTLTYEA
200
VHQTTQVGLG
210
QSLCIGIGGD
220
PFNGTNFIDC
230
LDVFLKDPAT
240
EGIVLIGEIG
250
GHAEENAAEF
260
LKEHNSGPKA
270
KPVVSFIAGI
280
TAPPGRRMGH
290
AGAIIAGGKG
300
GAKEKISALQ
310
SAGVIVSMSP
320
AQLGTCMYKV
KFKNSALL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.