Search Results
Overview
| Uniprot ID | A0A8I6AC07 |
|---|---|
| Protein Name | Sidoreflexin |
| Gene Name | Sfxn1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | ENELWRAKYAYDSAF |
| 80 | EQLENARKVVHDYRQ |
Function
Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine
Protein Sequence
10
MTKLAGCKRP
20
RWLPGDCLHE
30
DGRAQLPGSG
40
TMSGEVPPNI
50
NIKEPRWDQS
60
TFIGRASHFF
70
TVTDPRNILL
80
TNEQLENARK
90
VVHDYRQGIV
100
PAGLTENELW
110
RAKYAYDSAF
120
HPDTGEKMTL
130
IGRMSAQVPM
140
NMTITGCMMT
150
FYRTTPAVLF
160
WQWINQSFNA
170
VVNYTNRSGD
180
APLTVNELGT
190
AYVSATTGAV
200
ATALGLNALT
210
KHVSPLIGRF
220
VPFAAVAAAN
230
CINIPLMRQR
240
ELKVGIPVTD
250
ENGTRLGEST
260
NAAKQAITQV
270
VISRILMAAP
280
GMAIPPFIMN
290
TLEKKAFLKR
300
FPWMSAPIQV
310
TLVGFCLVFA
320
TPLCCALFPQ
330
KSSMSVTSLE
340
DELQASIQKS
350
HPELRRVYFN
KGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Molecular Function | GO:0015180 | L-alanine transmembrane transporter activity |
| Molecular Function | GO:0015194 | L-serine transmembrane transporter activity |
| Molecular Function | GO:0015075 | monoatomic ion transmembrane transporter activity |
| Biological Process | GO:0006730 | one-carbon metabolic process |
| Biological Process | GO:0140300 | serine import into mitochondrion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.