Search Results

Overview

Uniprot ID	A0A8I6AC75
Protein Name	Calpastatin
Gene Name	Cast
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
239	KSTGESSKAQSAGVT

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Protein Sequence

10 MSRPGPKPAA 20 SSRPRRGAAA 30 SHTQEHVNEK 40 NIGSSSKPAE 50 KKGSDEVISV 60 LVTFETHDLG 70 HSQRYLVLSL 80 FYLCSQTKFQ 90 DAPSADGESV 100 AGGVTVATAS 110 DKVVVKKKEK 120 KSLTPTLPME 130 STLNKLSDKS 140 GVNAALDDLI 150 DTLGECEDTN 160 KDDPPYTGPV 170 VLDPMDSTYL 180 EALGIKEGTI 190 PPEYRKLLEK 200 NEAITGPLPD 210 SPKPMGIDHA 220 IDALSSDFTC 230 SSPTGKQTEK 240 EKSTGESSKA 250 QSAGVTRSAV 260 PPQEKKRKVE 270 EEVMNDQALQ 280 ALSDSLGTRQ 290 PDPQSHLRQA 300 KQVKEAKAKE 310 ERQEKCGEDE 320 DTVPAEYRLK 330 PAKDKDGKPL 340 LPEPEETSKC 350 LSESELIGEL 360 SADFVQPTYQ 370 EKPSMPAAKI 380 KKGVVPDDAV 390 ETLARSLGTR 400 KEDPEDEKSL 410 VDKVKEKAKE 420 EDHEKLGEKE 430 ETIPPDYRLE 440 IVKDKDGKPL 450 LPKEAEEQLP 460 PLSDDFLLDA 470 LSQDFSSPAN 480 ILSLGFEDAK 490 LSAAVSETVS 500 QVPAPSNHTA 510 APPPGTERRD 520 KELDDALDEL 530 SDSLGQRQPD 540 PDENKPLDDK 550 VKEKIKAEHS 560 EKLGERDDTI 570 PPEYRHLLDN 580 DGKDKPEKPL 590 TKNTEKPGQD 600 QDPIDALSED 610 LDSCPPTTET 620 SQNTTKVLCF 630 FIPISLKYPY F

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.