Search Results
Overview
| Uniprot ID | A0A8I6ACB9 |
|---|---|
| Protein Name | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| Gene Name | Dlst |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 165 | GAAPAKAKPAEAPAT |
| 214 | SKPVSAIKPTAAPPL |
| 228 | LAEAGAAKGLRSEHR |
| 278 | QEMRARHKDAFLKKH |
| 364 | TINELGEKARKNELA |
Function
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A
Protein Sequence
10
MLSRSRCVSR
20
AFSRSLSAFQ
30
KVRCWLRVVL
40
FLAGVSLCQG
50
PGYPDNTDSK
60
FKHWILSKKT
70
IKKTEWALMV
80
FLFCFSLEND
90
VITVQTPAFA
100
ESVTEGDVRW
110
EKAVGDAVAE
120
DEVVCEIETD
130
KTSVQVPSPA
140
NGIIEALLVP
150
DGGKVEGGTP
160
LFTLRKTGAA
170
PAKAKPAEAP
180
ATAHKAAPEA
190
PAAPPPPVAP
200
VPTQMPPVPS
210
PSQPPSSKPV
220
SAIKPTAAPP
230
LAEAGAAKGL
240
RSEHREKMNR
250
MRQRIAQRLK
260
EAQNTCAMLT
270
TFNEVDMSNI
280
QEMRARHKDA
290
FLKKHNLKLG
300
FMSAFVKASA
310
FALQEQPVVN
320
AVIDDATKEV
330
VYRDYIDISV
340
AVATPRGLVV
350
PVIRNVETMN
360
YADIERTINE
370
LGEKARKNEL
380
AIEDMDGGTF
390
TISNGGVFGS
400
LFGTPIINPP
410
QSAILGMHGI
420
FDRPVAVGGK
430
VEVRPMMYVA
440
LTYDHRLIDG
450
REAVTFLRKI
460
KAAVEDPRVL
LLDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0045252 | oxoglutarate dehydrogenase complex |
| Molecular Function | GO:0004149 | dihydrolipoyllysine-residue succinyltransferase activity |
| Biological Process | GO:0033512 | L-lysine catabolic process to acetyl-CoA via L-saccharopine |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.