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Overview

Uniprot IDA0A8I6ACF8
Protein NameATP-dependent chromatin remodeler CHD4
Gene NameChd4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
290 KVAPLKIKLGGFGSK

Function

ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis

Protein Sequence

10 MASGLGSPSP 20 CSAGSEEEDM 30 DALLNNSLPP 40 PHPENEDDPE 50 EDLSEAETPK 60 LKKKKKPKKP 70 RDPKIPKSKR 80 QKKELGDSSG 90 EGPEFVEEDE 100 EAALRSDSEG 110 SDYTPGKKKK 120 KKLGPKKEKK 130 SKSKRKEEEE 140 EEDDDDDSKE 150 PKSSAQLLED 160 WGMEDIDHVF 170 SEEDYRTLTN 180 YKAFSQFVRP 190 LIAAKNPKIA 200 VSKMMMVLGA 210 KWREFSTNNP 220 FKGSSGASVA 230 AAAAAAVAVV 240 ESMVTATEVA 250 PPPPPVEVPI 260 RKAKTKEGKG 270 PNARRKPKGS 280 PRVPDAKKPK 290 PKKVAPLKIK 300 LGGFGSKRKR 310 SSSEDDDLDV 320 ESDFDDASIN 330 SYSVSDGSTS 340 RSSRSRKKLR 350 TAKKKKKGEE 360 EVTAVDGYET 370 DHQDYCEVCQ 380 QGGEIILCDT 390 CPRAYHMVCL 400 DPDMEKAPEG 410 KWSCPHCEKE 420 GIQWEAKEDN 430 SEGEEILEEV 440 GGDPEEEDDH 450 HMEFCRVCKD 460 GGELLCCDTC 470 PSSYHIHCLN 480 PPLPEIPNGE 490 WLCPRCTCPA 500 LKGKVQKILI 510 WKWGQPPSPT 520 PVPRPPDADP 530 NTPSPKPLEG 540 RPERQFFVKW 550 QGMSYWHCSW 560 VSELQLELHC 570 QVMFRNYQRK 580 NDMDEPPSGD 590 FGGDEEKSRK 600 RKNKDPKFAE 610 MEERFYRYGI 620 KPEWMMIHRI 630 LNHSVDKKGH 640 VHYLIKWRDL 650 PYDQASWESE 660 DVEIQDYDLF 670 KQSYWNHREL 680 MRGEEGRPGK 690 KLKKVKLRKL 700 ERPPETPTVD 710 PTVKYERQPE 720 YLDATGGTLH 730 PYQMEGLNWL 740 RFSWAQGTDT 750 ILADEMGLGK 760 TVQTAVFLYS 770 LYKEGHSKGP 780 FLVSAPLSTI 790 INWEREFEMW 800 APDMYVVTYV 810 GDKDSRAIIR 820 ENEFSFEDNA 830 IRGGKKASRM 840 KKEASVKFHV 850 LLTSYELITI 860 DMAILGSIDW 870 ACLIVDEAHR 880 LKNNQSKFFR 890 VLNGYSLQHK 900 LLLTGTPLQN 910 NLEELFHLLN 920 FLTPERFHNL 930 EGFLEEFADI 940 AKEDQIKKLH 950 DMLGPHMLRR 960 LKADVFKNMP 970 SKTELIVRVE 980 LSPMQKKYYK 990 YILTRNFEAL 1000 NARGGGNQVS 1010 LLNVVMDLKK 1020 CCNHPYLFPV 1030 AAMEAPKMPN 1040 GMYDGSALIR 1050 ASGKLLLLQK 1060 MLKNLKEGGH 1070 RVLIFSQMTK 1080 MLDLLEDFLE 1090 HEGYKYERID 1100 GGITGNMRQE 1110 AIDRFNAPGA 1120 QQFCFLLSTR 1130 AGGLGINLAT 1140 ADTVIIYDSD 1150 WNPHNDIQAF 1160 SRAHRIGQNK 1170 KVMIYRFVTR 1180 ASVEERITQV 1190 AKKKMMLTHL 1200 VVRPGLGSKT 1210 GSMSKQELDD 1220 ILKFGTEELF 1230 KDEATDGGGD 1240 NKEGEDSSVI 1250 HYDDKAIERL 1260 LDRNQDETED 1270 TELQGMNEYL 1280 SSFKVAQYVV 1290 REEEMGEEEE 1300 VEREIIKQEE 1310 SVDPDYWEKL 1320 LRHHYEQQQE 1330 DLARNLGKGK 1340 RIRKQVNYND 1350 GSQEDRDWQD 1360 DQSDNQSDYS 1370 VASEEGDEDF 1380 DERSEAPRRP 1390 SRKGLRNDKD 1400 KPLPPLLARV 1410 GGNIEVLGFN 1420 ARQRKAFLNA 1430 IMRYGMPPQD 1440 AFTTQWLVRD 1450 LRGKSEKEFK 1460 AYVSLFMRHL 1470 CEPGADGAET 1480 FADGVPREGL 1490 SRQHVLTRIG 1500 VMSLIRKKVQ 1510 EFEHVNGRWS 1520 MPELAEVEEN 1530 KKMSQPGSPS 1540 PKTPTPSTPG 1550 DTQPNTPAPV 1560 PPAEDGIKIE 1570 ENSLKEEEST 1580 EGEKEVKPTA 1590 PEVTVECAQP 1600 PAPAPAPASG 1610 PGPTPGPAPA 1620 PEDDKAPAEP 1630 PEGEEKVEKA 1640 EVKERAEEPM 1650 ETESKGTTEV 1660 EKAEEKSAVD 1670 LTPIVVEDKG 1680 RCYVKYAILS 1690 SFLLSNLPLN 1700 SSSELHSLWQ 1710 NEERAATVTK 1720 KTYEIWHRRH 1730 DYWLLAGIIN 1740 HGYARWQDIQ 1750 NDPRYAILNE 1760 PFKGEMNRGN 1770 FLEIKNKFLA 1780 RRFKLLEQAL 1790 VIEEQLRRAA 1800 YLNMSEDPSH 1810 PSMALNTRFA 1820 EVECLAESHQ 1830 HLSKESMAGN 1840 KPANAVLHKV 1850 LKQLEELLSD 1860 MKADVTRLPA 1870 TIARIPPVAV 1880 RLQMSERNIL 1890 SRLANRAPEP PPQQV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.