Search Results
Overview
| Uniprot ID | A0A8I6ACH7 |
|---|---|
| Protein Name | Cytosolic acyl coenzyme A thioester hydrolase |
| Gene Name | Acot7 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | LSLKNVDKVLEVPPI |
| 199 | RKRYEAQKLERMETK |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain
Protein Sequence
10
TAPPLPSSFM
20
APPRLIHSAP
30
GLLDTCSQIP
40
PPPSPPPPAV
50
AAKMSGPTTD
60
TPAAIQICRI
70
MRPDDANVAG
80
NVHGGTILKM
90
IEEAGVIIST
100
RHCNSQNGER
110
CVAALARVER
120
TDFLSPMCIG
130
EVAHVSAEIT
140
YTSKHSVEVQ
150
VHVLSENILT
160
GTKKLTNKAT
170
LWYVPLSLKN
180
VDKVLEVPPI
190
VYLRQEQEEE
200
GRKRYEAQKL
210
ERMETKWRNG
220
DIVQPILNPE
230
PNTVSYSQSS
240
LIHLVGPSDC
250
TLHGFVHGGV
260
TMKLMDEVAG
270
IVAARHCKTN
280
IVTASVDAIN
290
FHDKIRKGCV
300
ITISGRMTFT
310
SNKSMEIEVL
320
VDADPVVDNS
330
QKRYRAASAF
340
FTYVSLNQEG
350
KPLPVPQLVP
360
ETEDEKKRFE
370
EGKGRYLQMK
380
AKRQGHTEPQ
P
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0047617 | fatty acyl-CoA hydrolase activity |
| Biological Process | GO:0006631 | fatty acid metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.