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Overview

Uniprot ID	A0A8I6ACJ2
Protein Name	V-type proton ATPase subunit H
Gene Name	Atp6v1h
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
119	FDYAKRSKSTAWPYF
353	LEWSPVHKSEKFWRE
368	NAVRLNEKNYELLKI
416	VIEQLGGKQLVMNHM

Function

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes

Protein Sequence

10 MTKMDIRGAV 20 DAAVPTNIIA 30 AKAAEVRANK 40 VNWQSYLQGQ 50 MISAEDCEFI 60 QRFEMKRCSE 70 EKQEMLQTEG 80 SQCAKTFINL 90 MTHISKEQTV 100 QYILTMVDDM 110 LQENHQRVSI 120 FFDYAKRSKS 130 TAWPYFLPML 140 NRQDPFTVHM 150 AARIIAKLAA 160 WGKELMEGSD 170 LNYYFNWIKT 180 QLSSQSSQYV 190 QCVAGCLQLM 200 LRVNEYRFAW 210 VEADGVNCIM 220 GVLSNKCGFQ 230 LQYQMIFSIW 240 LLAFSPQMCE 250 HLRRYNIIPV 260 LSDILQESVK 270 EKVTRIILAA 280 FRNFLEKSTE 290 RETRQEYALA 300 MIQCKVLKQL 310 ENLEQQKYDD 320 EDISEDIKFL 330 LEKLGESVQD 340 LSSFDEYSSE 350 LKSGRLEWSP 360 VHKSEKFWRE 370 NAVRLNEKNY 380 ELLKILTKLL 390 EVSDDPQVLA 400 VAAHDVGEYV 410 RHYPRGKRVI 420 EQLGGKQLVM 430 NHMHHEDQQV 440 RYNALLAVQK 450 LMVHNWYVSM 460 SISPAHGSVN 470 SHMLILEYLG 480 KQLQSEQPQT AAARS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.