Search Results
Overview
| Uniprot ID | A0A8I6ACT3 |
|---|---|
| Protein Name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| Gene Name | Naxd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 47 | IVPALTSKKHKGQDG |
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Protein Sequence
10
MGIRCVAIRA
20
CGGVLQRALS
30
LHTAHATKDM
40
DNLFQLVRNI
50
VPALTSKKHK
60
GQDGRIGIVG
70
GCQEYTGAPY
80
FAGISALKVG
90
ADLTHVFCAR
100
EAAPVIKSYS
110
PELIVHPVLD
120
SSDAVEEVEK
130
WLPRLHALVV
140
GPGLGRDDLL
150
LNNVRGILES
160
TKARDIPVVI
170
DADGLWLIAQ
180
RPALVHGYQK
190
AVLTPNHVEF
200
SRLWDAVLSS
210
PMDTSNHSGS
220
VLKLSQALGN
230
ITIVQKGEQD
240
LISNGQQAPA
250
RSWWLPGVRA
260
HSQGSVTIWP
270
SRSTGVPQPL
PT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.