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Overview

Uniprot IDA0A8I6ADT2
Protein NameVacuolar proton pump subunit B
Gene NameAtp6v1b2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
107 GTSGIDAKKTSCEFT
108 TSGIDAKKTSCEFTG
402 PSLSRLMKSAIGEGM
459 EFLQKFEKNFITQGP
80 LTLPDGTKRSGQVLE

Function

Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load

Protein Sequence

10 MALRAMRGIV 20 NGAAPELPVP 30 TGGPMAGARE 40 QALAVSRNYL 50 SQPRLSEYGN 60 VSRGGNGIHF 70 PHRFPRYAEI 80 VHLTLPDGTK 90 RSGQVLEVSG 100 SKAVVQVFEG 110 TSGIDAKKTS 120 CEFTGDILRT 130 PVSEDMLGRV 140 FNGSGKPIDR 150 GPVVLAEDFL 160 DIMGQPINPQ 170 CRIYPEEMIQ 180 TGISAIDGMN 190 SIARGQKIPI 200 FSAAGLPHNE 210 IAAQICRQAG 220 LVKKSKDVVD 230 YSEENFAIVF 240 AAMGVNMETA 250 RFFKSDFEEN 260 GSMDNVCLFL 270 NLANDPTIER 280 IITPRLALTT 290 AEFLAYQCEK 300 HVLVILTDMS 310 SYAEALREVS 320 AAREEVPGRR 330 GFPGYMYTDL 340 ATIYERAGRV 350 EGRNGSITQI 360 PILTMPNDDI 370 THPIPDLTGY 380 ITEGQIYVDR 390 QLHNRQIYPP 400 INVLPSLSRL 410 MKSAIGEGMT 420 RKDHADVSNQ 430 LYACYAIGKD 440 VQAMKAVVGE 450 EALTSDDLLY 460 LEFLQKFEKN 470 FITQGPYENR 480 TVYETLDIGW 490 QLLRIFPKEM 500 LKRIPQSTLS 510 EFYPRDSAKH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0042470 melanosome
Cellular Component GO:0033180 proton-transporting V-type ATPase, V1 domain
Cellular Component GO:0030672 synaptic vesicle membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0019725 cellular homeostasis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.