Search Results

Overview

Uniprot ID	A0A8I6ADV1
Protein Name	Calpastatin
Gene Name	Cast
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
251	KSTGESSKAQSAGVT

Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue

Protein Sequence

10 MSRPGPKPAA 20 SSRPRRGAAA 30 SHTQEHVNEK 40 NIGSSSKPAE 50 KKGSDEVISA 60 IVIPQTLPKH 70 ASDTGSKHAH 80 KEKALSRSNE 90 QIVSEKSSES 100 KVNAPSADGE 110 SVAGGVTVAT 120 ASDKVVVKKK 130 EKKSLTPTLP 140 MESTLNKLSD 150 KSGVNAALDD 160 LIDTLGECED 170 TNKDDPPYTG 180 PVVLDPMDST 190 YLEALGIKEG 200 TIPPEYRKLL 210 EKNEAITGPL 220 PDSPKPMGID 230 HAIDALSSDF 240 TCSSPTGKQT 250 EKEKSTGESS 260 KAQSAGVTRS 270 AVPPQEKKRK 280 VEEEVMNDQA 290 LQALSDSLGT 300 RQPDPQSHLR 310 QAKQVKEAKA 320 KEERQEKCGE 330 DEDTVPAEYR 340 LKPAKDKDGK 350 PLLPEPEETS 360 KCLSESELIG 370 ELSADFVQPT 380 YQEKPSMPAA 390 KIKKGVVPDD 400 AVETLARSLG 410 TRKEDPEDEK 420 SLVDKVKEKA 430 KEEDHEKLGE 440 KEETIPPDYR 450 LEIVKDKDGK 460 PLLPKEAEEQ 470 LPPLSDDFLL 480 DALSQDFSSP 490 ANILSLGFED 500 AKLSAAVSET 510 VSQVPAPSNH 520 TAAPPPGTER 530 RDKELDDALD 540 ELSDSLGQRQ 550 PDPDENKPLD 560 DKVKEKIKAE 570 HSEKLGERDD 580 TIPPEYRHLL 590 DNDGKDKPEK 600 PLTKNTEKPG 610 QDQDPIDALS 620 EDLDSCPPTT 630 ETSQNTTKVL 640 CFFIPISLKY PYF

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.